American Journal of Drug Discovery and Development2150-427x2150-4296Academic Journals Inc.10.3923/ajdd.2014.1.11MehtaMeenu SatijaSaurabh NandaArun GargMunish 1201441Boswellic Acids (BAs) are the main ingredients of Boswellia serrata
(Family: Burseraceae) gum resin extract for the treatment of a variety of inflammatory
diseases besides acting as both internal and external stimulant, expectorant,
diuretic and stomachic. Despite its multipurpose benefits, BAs have low oral
bioavailability especially 11-keto-β-boswellic acid (KBA) and 3-acetyl-11-keto-β-boswellic
acid (AKBA), (the most therapeutically potential BAs) because these BAs are
lipophilic in nature and not solubilises into the intestinal fluid thus limiting
its systemic availability. For decades, many attempts have been made to compensate
for these disadvantages, with the development of improved delivery platforms
as the feasible approaches. The past ten years has witnessed the encouraging
progress in the use of nano scale drug delivery systems on BAs such as loading
BAs into liposomes, solid lipid nanoparticles as well as the latest reported
technologies such as niosomes, phytosomes and nanomicelles etc. This review
summarizes the recent works on the design and development of nanoscale delivery
systems of BAs, with the goal of harnessing the true difficulties of this multifunctional
agent in the clinical arena.]]>Altmann, A., D. Poeckel, L. Fischer, M. Schubert-Zsilavecz, D. Steinhilber and O. Werz,20042+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes.]]>141223232Ammon, H.P.T., T. Mack, G.B. Singh and H. Safayhi,1991Boswellia serrata.]]>57203207Attia, I.A., S.A. El-Gizawy, M.A. Fouda and A.M. Donia,20078206212Aungst, B.J.,199382979987Azmin, M.N., A.T. Florence, R.M. Handjani-Vila, F.B. Stuart, G. Vanlerberghe and J.S. Whittaker,198537237242Bhattacharya, S.,20092225232Bombardelli, E. and M. Spelta,19911066976Bombardelli, E.,1991130431438Bombardelli, E., S.B. Curri, R. Loggia, N. Della, P. Del, A. Tubaro and P. Gariboldi,19896019Buchele, B. and T. Simmet,2003795355362Charman, S.A., W.N. Charman, M.C. Rogge, T.D. Wilson, F.J. Dutko and C.W. Pouton,199298793D`Mello, P. and M. Rana,2010Psidium guajava extract and its phospholipid complex in paracetamol induced hepatic damage in rats.]]>28593Fartyal, S., S.K. Jha, M.S. Karchuli, R. Gupta and A. Vajpayee,201137681Kwon,G.S. and O. Teruo,199621107116Goel, A., F.G. Ahmad, R.M. Singh and G.N. Singh,201062272278Gursoy, N.R. and S. Benita,200458173182Hoernlein, R.F., T. Orlikowsky, C. Zehrer, D. Niethammer and E.R. Sailer et al.,1999288613619Huh, K.M., S.C. Lee, Y.W. Cho, J. Lee, J.H. Jeong and K. Park,20051015968Humberstone, A.J. and W.N. Charman,199725103128Junyaprasert, V.B., V. Teeranachaideekul and T. Supaperm,20089851859Kakkar, V., S. Singh, D. Singla and I.P. Kaur,201155495503Kasali, A.A., A.M. Adio, O.E. Kundayo, A.O. Oyedeji, A.O.E.M. Adefenwa and B.A. Adeniyi,2002Boswellia serrata Roxb. Fam. Burseraceae bark.]]>5173175Reddy, K.G. and S.C. Dhar,198736205217Kidd, P.M.,200914226246Li, D.C., X.K. Zhong, Z.P. Zeng, J.G. Jiang and L. Li et al.,2009138103112Lu, M., L. Xia, H. Hua and Y. Jing,20086811801186MacGregor, T.R., J.P. Sabo, S.H. Norris, P. Johnson, L. Galitz and S. McCallister,20045371382Maiti, K., K. Mukherjee, A. Gantait, B.P. Saha and P.K. Mukherjee,2007330155163Malam, M., M. Loizidou and A.M. Seifalian,200930592599Moussaieff, A. N.A. Shein, J. Tsenter, S. Grigoriadis and C. Simeonidou et al.,2008Boswellia carterii.]]>2813411352Murray, D.,20082008Nandan, C.D., P. Reshmi, S. Uthaman, Saji and K.S. Snima et al.,201313037Nasr, M.,2010In-vitro and in-vivo evaluation of proniosomes containing celecoxib for oral administration.]]>118589Patel, D. and K.K. Sawant,20096419424Kruger, P., R. Daneshfar, G.P. Eckert, J. Klein and D.A. Volmer et al.,2008in vitro and in vivo.]]>3611351142Poeckel, D. and O. Werz,20061333593369Porter, C.H.J. and W.N. Charman,2001506180Pouton, C.W. and C.J.H. Porter,200860625637Pungle, P., M. Banavalikar, A. Suthar, M. Biyani and S. Mengi,2003Boswellia serrata Roxb.]]>4114601462Reising, K., J. Meins, B. Bastian, G. Eckert, W.E. Mueller, M. Schubert-Zsilavecz and M. Abdel-Tawab,20057766406645Safayhi, H., T. Mack, J. Sabieraj, M. M. Anazodo, L.R. Subramanian and H.P. Ammon,199226111431146Sahu, A., U. Bora, N. Kasoju and P. Goswami,2008417521761Sailer, E.R., L.R. Subramanian, B. Rall, R.F. Hoernlein, H.P. Ammon and H. Safayhi,1996117615618Shah, B.A., G.N. Qazi and S.C. Taneja,2009267289Sharma, A., N.K. Gupta and V.K. Dixit,201017587595Shi, F., J.H. Zhao, Y. Liu, Z. Wang, Y.T. Zhang and N.P. Feng,2012720332043Singh, B., S. Bandopadhyay, R. Kapil and O.P. Katare,200833846Singh, G.B. and C.K. Atal,1986Boswellia serrata, a new non-steroidal anti-inflammatory agent.]]>18407412Singh, G.B., S. Singh and S. Bani,199638185Rajera, R., K. Nagpal, S.K. Singh and D.N. Mishra,201134945953Sterk, V., B. Buchele and T. Simmet,20047011551160Terreno, E., D. Delli Castelli, C. Cabella, W. Dastru and A. Sanino et al.,2008519011912Upaganlawar, A. and B. Ghule,2009Boswellia serrata Roxb.-Mini Review.]]>13766774Varshosaz, J., A. Pardakhty, V. Hajhashemi and A.R. Najafabadi,200310251262Vora, B., A.J. Khopade and N.K. Jain,199854149165Wang, M. and M. Thanou,2010629099Yadav, K., D. Yadav, K. Saroha, S. Nanda, P. Mathur and N. Syan,20102189198Xiao, Y., Y. Song, Z. Chen and Q. Ping,20063077782Zhu, R.R., L.L. Qin, M. Wang, S.M. Wu and S.L. Wang et al.,20092009Zutsi, U., P.G. Rao and S. Kaur,1986Boswellia serrata Roxb.]]>18182183