American Journal of Drug Discovery and Development2150-427x2150-4296Academic Journals Inc.10.3923/ajdd.2013.293.297Acanthus ilicifolius
Leaves Against Staphylococcus aureus: An In silico Approach]]>SekaranGanesh VennilaJ. Jannet BaskarAnnie Mercy Arul 4201334Acanthus ilicifolius is lesser-known medicinal plant is used as medicine
in traditional systems. Staphylococcus aureus is inducing many infections
and it can infect tissues when the skin and mucosal barriers. The plant Acanthus
ilicifolius GC-MS have reported the following phytochemicals, 26.27-Di (nor)-cholest-5,7,23-trien-22-ol,
3-methoxymethoxy, 9H-purin-6-amine, N, 9-bis (trimethylsilyl)-8-((trimethylsilyl)
Oxy), Cyano colchicines and 3beta-methoxy-5-choleston-19-oic acid against a
12 essential protein and synthetic drug of S. aureus was collected through
literature survey. S. aureus was studied zone of inhibition in different
concentrations against microorganisms and essential proteins were used as target
which were docked using phytochemicals (ligands) found in A. ilicifolius
leaves. In the present study, to analyze the effect of A. ilicifolius
against S. aureus through docking and inhibition studies, that A.
ilicifolius has significant activity against S. aureus. This research
was helpful attempt to the drug discovery in S. aureus.]]>Bartlett, A.H. and K.G. Hulten,201029860861Babu, B.H., B.S. Shylesh and J. Padikkala,2001Acanthus ilicifolius.]]>72272277Bigos, M. and A. Denys,200814101109DeLeo, F.R., M. Otto, B.N. Kreiswirth and H.N. Chambers,2010Staphylococcus aureus.]]>37515571568Ghosh, S., A. Nie, J. An and Z. Huang,200610194202Bala, J.M., J.J. Vennila, S. Ganesh and S. Singh,2011418091812Lakshmi, M., S. Rajalakshmi, M. Parani, C.S. Anuratha and A. Parida,1997Acanthus ilicifolius Linn. (Acanthaceae).]]>9411211127Agshikar, N.V., V.R. Naik, G.J. Abraham, C.V. Reddy, S.W. Naqvo and P.K. Mittal,1979Acanthus illicifolius Linn.]]>1712571258Okunade, M.B., J.A. Adejumobi, M.O. Ogundiya and A.L. Kolapo,200714952Perez, C., A. Pauli and P. Bazerque,199015113115Rafee, Y., N. Abdel-Haq, B. Asmar, T. Salimnia, C.V. Pharm, M.J.R. Pharm and M. Amjad,2012Staphylococcus aureus nasal colonization in household contacts of children with community acquired disease.]]>2012Wang, J.T., C.H. Liao, C.T. Fang, W.C. Chie, M.S. Lai, T.L. Lauderdale and S.C. Chang,2010Staphylococcus aureus acquired infection or colonization in intensive-care-unit patients.]]>4844394444