American Journal of Drug Discovery and Development2150-427x2150-4296Academic Journals Inc.10.3923/ajdd.2013.279.285Turbinaria turbinata: A Brown Seaweed Species of Malaysian Origin]]>HammedAdemola Monsur Asiyanbi-HammedTawakalit Tope JaswirIrwandi AmidAzura AlamMd. Zahangir 4201334This study investigates effect of drying method on anti-inflammatory properties
and composition of water soluble extracts obtained from brown seaweed, Turbinaria
turbinata. T. turbinata was air-oven dried (50°C for 24 h) and
freeze dried prior to extraction with water to obtained crude water extract.
The crude extracts were partitioned into polyphenol and polysaccharide fractions.
Method of drying did not affect the yield of water soluble components. Composition
analysis revealed that extracts obtained from freeze dried biomass contain higher
total sugar, uronic acid and polyphenol content, except in crude extract where
oven dried matter was higher in total sugar and uronic acid content. Anti-inflammatory
potential of the extracts was investigated using inhibition of nitric oxide
synthesis in RAW 264.7 macrophage cell line. Although, all extracts reduce secretion
of Nitric Oxide (NO) differently, percentage NO inhibition between polyphenol
fractions of freeze dried and oven dried sample was not significant. Freeze
drying retain anti-inflammatory activities of polysaccharide fraction compared
to oven drying. Temperature used during oven drying did not cause damage to
bioactive compounds in polyphenol fraction of the seaweed. Therefore, either
of the two drying methods can be used for dehydration of seaweed but freeze
drying is preferred over oven drying when targeting polysaccharide.]]>Chin, S.K., C.L. Law and P.G. Cheng,2011Ganoderma lucidum.]]>33843Cui, Z.W., S.Y. Xu, D.W. Sun and W. Chen,2006Ganoderma lucidum extraction by combined microwave vacuum and conventional vacuum drying.]]>24595599Ehrlich, H.,2010Vol. 1,pp: 1-5pp: 1-5Gupta, S. and N. Abu-Ghannam,201122315326Gupta, S., S. Cox and N. Abu-Ghannam,20114412661272Hung, P.V. and T.L. Duy,201219327332Li, Y.X., I. Wijesekara, Y. Li and S.K. Kim,20114622192224Madrau, M.A., A. Piscopo, A.M. Sanguinetti, A. Del Caro, M. Polana, F.V. Romeo and A. Piga,2009228441448Nour, V., I. Trandafir and M.E. Ionica,201121524Wu, L., Z. Huang, P. Qin and G. Ren,201253678685Jaswir, I., H.A. Monsur and H.M. Salleh,2011101884718854Yoon, J.H., A.S. Rokem, M.A. Silver, M.J. Minzenberg, S. Ursu, J.D. Ragland and C.S. Carter, 20093510781084Blumenkratz, N. and G. Asboe-Hansen,197354484489