American Journal of Drug Discovery and Development2150-427x2150-4296Academic Journals Inc.10.3923/ajdd.2013.263.270in vitro]]>HosseiniSeyed Abdolhakim MahmoodiMehdi HakhamaneshiMohammad Saeed HosseiniShadi AbdiMohammad ZareiSadegh Hosseini-ZijoudSeyed-Mostafa HosseiniJavad 4201334Hyperglycemia in diabetes causes glycosylation of the body proteins that leads
to a change in their conformation and function. In this study the influence
of the Aloe vera's extracts on the inhibition of the Albumin glycosylation reaction
and on the breaking the bond between Albumin and glucose was surveyed in
vitro. The influence of Aloe vera at 0.1, 0.2, 0.5 and 1 g dL-1
concentrations in two states; influence on the inhibition reaction of Albumin
glycosylation and influence on the bond breaking between Albumin and glucose
was surveyed in vitro. The rate of glycosylation was measured by thiobarbituric
acid (TBA) and p<0.05 was considered as significant Level. Aloe vera's extract
can inhibit significantly the Albumin glycosylation reaction in all concentrations
except in 1 g dL-1 concentration and it has maximum inhibitory effect
in 0.1 g dL-1 concentration (p<0.05) and the rate of this inhibition
was time dependent. Additionally, it could break the Albumin-glucose bond and
the maximum effect was seen with 0.1 g dL-1 concentration (p<0.05).
The results demonstrate that Aloe vera inhibits the glycosylation of the Albumin
and also break the Albumin-glucose bond down, thus it has a hypoglycemic effect.]]>Agarwal, O.P.,198536485492Ahmed, N.,200567321Alpers, D.H.,200925116121Asgary, S., G. Naderi and M. Gharipoor,2004In vitro non-enzymatic Glycosylation of proteins.]]>819Bonnefont-Rousselot, D.,20025561568Chen, H.C., W.T. Hsieh, W.C. Chang and J.G. Chung,2004in vitro G2/M arrest of cell cycle in human promyelocytic leukemia HL-60 cells. ]]>4212511257Delers, F., G. Strecker and R. Engler,198866208217Dolhofer, R., O. Wieland and R. Ambrose,2001Hunt, J.V., M.A. Bottoms and M.J. Mitchinson,1993291529535Kuzuya, H., I. Tamai, H. Beppu, K. Shimpo and T. Chihara,20017529197Langmead, L., R.J. Makins and D.S. Rampton,2004Aloe vera gel in human colorectal mucosa in vitro.]]>19521527Muller, M.J., M.A. Hollyoak, Z. Moaveni, T.L. Brown, D.N. Herndon and J.P. Heggers,200329834836Nakagawa, T., T. Yokozawa, K. Terasawa, S. Shu and L.R. Juneja,20025024182422Peters, Jr.T.,198537161245Rahbar, S., O. Blumenfeld and H.M. Ranney,196936838843Rajasekaran, S., K. Sivagnanam and S. Subramanian,2005579096Safari, M., S. Nasrin and M. Kashani Kh.,2002In vitro.]]>17983Sheykh, N., M. Safari, K. Mani, M. Araghchian, F. Zeraati and S. Malakouti,2004In vitro albumin glycation.]]>104750Swamy, M.S. and E.C. Abraham,1989In vitro and In vivo.]]>3011201126Tanaka, M., E. Misawa, Y. Ito, N. Habara and K. Nomaguchi et al.,20062914181422Thorpe, S.R. and J.W. Baynes,199696977Virdi, J., S. Sivakami, S. Shahani, A.C. Suthar, M.M. Banavalikar and M.K. Biyani,2003Momordica charantia.]]>88107111Vogler, B.K. and E. Ernst,199949823828Can, A., N. Akev, N. Ozsoy, S. Bolkent, P.A. Bahriye, R. Yanardag and A. Okyar,2004Aloe vera leaf gel and pulp extracts on the liver in type-II diabetic rat models.]]>27694698