American Journal of Drug Discovery and Development2150-427x2150-4296Academic Journals Inc.10.3923/ajdd.2013.23.31NgalaR.A. SadiqueOsei GmagnaP.K. 1201331Regular physical exercise has been reported to be effective in the prevention
or delay of onset of type 2 diabetes, increases insulin sensitivity and ameliorates
glucose metabolism and therefore considered beneficial for type 2 diabetes mellitus
management. This study investigated the effect of physical exercise on glycaemic
control in patients with type 2 diabetes. Overnight fasted blood samples were
drawn from the median cubital vein on the anterior forearm of diabetics and
the control subjects into plain and fluoride oxalate tubes. The serum from the
plain tubes was used to estimate the lipid profile: Blood glucose, serum total
cholesterol, triglycerides, low-density lipoproteins, very low-density lipoproteins
and high-density lipoproteins were determined using an autoanalyser. The plasma
from the fluoridated anticoagulated blood was used to estimate the fasting blood
glucose. Malonyldialdehyde level in serum was estimated spectrophotometrically.
Anthropometric parameters; height, bodyweight and blood pressures were also
measured. Fasting blood glucose was significantly (p<0.05) reduced in the
subjects who had longer duration of exercise, triglycerides were significantly
(p<0.05) reduced even in mild exercise, whilst HDL was increased (p<0.05)
in subjects who did 3 h and over exercise per week. Malonyldialdehyde was significantly
(p<0.05) decreased even in moderate exercise. The study demonstrates that
exercise modulates fasting blood glucose, lipid profile, oxidative stress in
patients with type 2 diabetes and suggest that exercise may have therapeutic,
preventative and protective effects on diabetes mellitus and should therefore
be used to complement drug therapy.]]>Adubofour, K.O.M., F. Ofei, J. Mensah-Adubofour and S.K. Owusu,199349092Armstrong, A.M., J.E. Chestnutt, M.J. Gormley and I.S. Young,199621719726Bijlani, R.L., R.P. Vempati, R.K. Yadav, R.B. Ray and V. Gupta et al.,200511267274Boule, N.G., E. Haddad, G.P. Kenny, G.A. Wells and R.J. Sigal,200128612181227Bruce, C.R., A.D. Kriketos, G.J. Cooney and J.A. Hawley,2004472330Buege, J.A. and S.D. Aust,19781978pp: 302-310pp: 302-310Carr, A.,200334S73S78Decombaz, J., M.J. Arnaud, H. Milon, H. Moesch, G. Philippossian, A.L. Thelin and H. Howald,198352914Dela, F., J.J. Larsen, K.J. Mikines, T. Ploug, L.N. Petersen and H. Galbo,19954410101020Derouich, M. and A. Boutayeb,200235911917Goodyear, L.J. and B.B. Kahn,199849235261Gupta, M. and S. Chari,200621118122Harant, I., F. Marion-Latard, F. Crampes, I. de Glisezinski, M. Berlan, V. Stitch and D. Riviere,20022613731378Horowitz, J.F. and S. Klein,200072S558S563Ibanez, J., M. Izquierdo, I. Arguelles, L. Forga and J.L. Larrion et al.,200528662667LeBlanc, J., A. Nadeau, D. Richard and A. Tremblay,19813011191124Jill, L.L.,20029598292Kadiiska, M.B., B.C. Gladen, D.D. Baird, D. Germolec and L.B. Grahama et al.,20054 poisoning?]]>38698710Kim, J.D., B.P. Yu, R.J.M. McCarter, S.Y. Lee and J.T. Herlihy,1996208388Laaksonen, D.E. and C.K. Sen,20002000pp: 1105-1136pp: 1105-1136Lewis, G.F. and G. Steiner,1996123756Loh, K.C., A.C. Thai, K.F. Lui and W.Y. Ng,199625228232Mayer-Davis, E.J., R. D'Agostino Jr., A.J. Karter, S.M. Haffner, M.J. Rewers, M. Saad and R.N. Bergman,1998279669674Mehta, N. and M. Reilly,20056524Mullarkey, C.J., D. Edelstein and M. Brownlee,1990173932939National Heart Lung and Blood Institute,198834193201Peuchant, E., M.C. Delmas-Beauvieux, A. Couchouron, L. Dubourg and M.J. Thomas et al.,199720202207Steiner, G., D. Stewart and J.D. Hosking,19998410041010Stephens, J.W., M.P. Khanolkar and S.C. Bain,2009202321329Van Raaij, M.T., G.E. van den Thillart, M. Hallemeesch, P.H. Balm and A.B. Steffens,1995268R1163R1170Wing, R R., L.H. Epstein, M. Paternostro-Bayles, A. Kriska, M.P. Nowalk and W. Gooding,198831902909Wolfe, R.R., S. Klein, F. Carraro and J.M. Weber,1990258E382E389