American Journal of Drug Discovery and Development2150-427x2150-4296Academic Journals Inc.10.3923/ajdd.2013.220.224Fonseca-AlvesCarlos Eduardo Tiagua VicenteIgor Simoes CalazansSabryna Gouveia Laufer-AmorimRenee 4201334Prostate cancer is ranked as the second leading cause of cancer-related death
in men aged above 50 years and the long-term survival of patients with metastatic
disease has not changed significantly. This fact is related mainly to the limited
therapeutic options available. Despite numerous studies on PCa in humans, success
was not obtained in clinical trials of targeted therapies because of the difficulty
in standardizing an ideal animal model for application in clinical trials. The
use of dogs as a model for the clinical trials of new drugs can bring in higher
accuracy in assessing the response of tumors to the drugs tested, with the assumption
that the dog is a natural model of the disease and shares the same environment
as humans. Due of the importance of prostate carcinoma in man the goal of the
review is to identify the strengths of the dog as a model for the development
of new therapy for prostatic carcinoma.]]>Armbruster, D.A.,199339181195Bostwick, D.G. and J. Qian,200417360379Bell, F.W., J.S. Klausner, D.W. Hayden, D.A. Feeney and S.D. Johnston,199119916231630Cornell, K.K., D.G. Bostwick, D.M. Cooley, G. Hall and H.J. Harvey et al.,200045173183Ellwood-Yen, K., T.G. Graeber, J. Wongvipat, M.L. Iruela-Arispe and J. Zhang et al.,20034223238Fonseca-Alves, C.E., M.B.R. Faleiro, R. Laufer Amorim and V.M.B.D De Moura,201062596602Fonseca-Alves, C.E., A.G. Correa, H.L. Santos-Junior, F. Elias, S.S. Costa and V.M.B.D. De Moura,20123311571164Fonseca-Alves, C.E., M.M. Rodrigues, V.M. Moura, S.R. Rogatto and R. Laufer-Amorim,20132013LeRoy, B.E. and N. Northrup,2009180149162Karr, J.F., J.A. Kantor, P.H. Hand, D.L. Eggensperger and J. Schlom,19955524532462Lowseth, L.A., R.F. Gerlach, N.A. Gillett and B.A. Muggenburg,199027347353Owen, L.N.,1980Pages: 53Pages: 53Vail, D.M., I.D. Kurzman, P.C. Glawe, M.G. O'Brien and R. Chun et al.,200250131136Teske, E., E.C. Naan, E.M. Van Dijk, E. Van Garderen and J.A. Schalken,2002197251255Lamb, D.J. and L. Zhang,20051353009S3015SZhang, H., M.H. Muders, J. Li, F. Rinaldo, D.J. Tindall and K. Datta,20086887708778