American Journal of Drug Discovery and Development2150-427x2150-4296Academic Journals Inc.10.3923/ajdd.2012.32.39Myristica fragrans on Melanisation and Conidiation of Aspergillus niger]]>PoojaV. SanwalHina BhatnagarSeema SrivastavaAshwani K. 1201221Myristica fragrans HOUTT has been traditionally used by Asian Indians to treat stomach pains, dysentery, vomiting and the symptoms of malaria. It is also chewed to prevent foul breath. The present study was carried out to elucidate the antifungal effect of four extracts; hexane, chloroform, methanolic and ethanolic extract obtained from Mace. The extracts were concentrated and re-suspended in DMSO. MIC80 was calculated by micro broth dilution method. Results have revealed the extracts to have good antifungal activity against Aspergillus niger and methanol and hexane extracts have been found to be most effective. Methanol and hexane extracts were also associated with de-melanization of Aspergillus niger. Further analysis revealed difference in the structure of the hyphal cell wall of methane and hexane extract treated cells.]]>Anam, K., A.G. Suganda, E.Y. Sukandar and L.B.S. Kardono,2010Terminalia muelleri Benth. against Staphylococcus aureus.]]>6407412Bahrami, A.M. and V. Ali,2010Scrophularia striata ethanolic leaves extracts on Staphylococcus aureus]]>6431434Dulger, B. and A. Gonuz,20043104107Jacobson, E.S.,200013708717Huffnagle, G.B., G.H. Chen, J.L. Curtis, R.A. McDonald, R.M. Strieter and G.B. Toews,1995Cryptococcus neoformans.]]>15535073516Nosanchuk, J.D. and A. Casadevall,20035203223Krishnan, N., S. Ramanathan, S. Sasidharan, V. Murugaiyah and S.M. Mansor,2010Cassia spectabilis leaf extracts.]]>6510514Lokhande, P.D., K.R. Gawai, K.M. Kodam, B.Y. Waghmare, A.R. Chabukswar and S.C. Jagdale,20061529533Sarwar, M., I.H. Attitalla and M. Abdollahi,20116867883Motamedi, H., E. Darabpour, M. Gholipour and S.M.S. Nejad,2010Plantago ovata and Oliveria decumbens endemic in iran against some pathogenic bacteria.]]>6117122NCCLS,1998Nosanchuk, J.D. and A. Casadevall,20065035193528Nosanchuk, J.D., P. Valadon, H. Feldmesser and A. Casadevall,1999Cryptococcus neoformans in murine infection.]]>19745750Polak, A. and D.M. Dixon,19893316391640Pooja, V., H. Sanwal, A. Goyal, S. Bhatnagar and A.K. Srivastava,2012Myristica fragrans and its effect against filamentous and non-filamentous fungus.]]>2012Saadabi, A.M.A.,20065907909Bonjar, G.H.S., S. Aghighi and A.K. Nik,20044405412Young, L.Y., C.M. Hull and J. Heitman,2003Candida lusitaniae.]]>4727172724