American Journal of Drug Discovery and Development2150-427x2150-4296Academic Journals Inc.10.3923/ajdd.2012.143.183AgrawalSarita GiriTapan Kumar TripathiDulal Krishna Ajazuddin AlexanderAmit 4201224Self micro-emulsifying drug delivery systems (SMEDDS) are vital tool for enhancement of oral bioavailability of hydrophobic drugs. These systems are currently of interest to the researchers because of their significant capability to act as drug delivery vehicles by incorporating a extensive range of drug molecules. The present communication embodies approaches in the design of lipid based formulation, evaluation processes, mechanism involved there in, updated with latest findings from literature reports and patents. Also, this comprehensive review offers an explicit discussion on vital possibilities of the SMEDDS in bioavailability improvement of various drugs. A pseudo ternary phase diagram is used for identifying the micro-emulsification region. 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