American Journal of Drug Discovery and Development2150-427x2150-4296Academic Journals Inc.10.3923/ajdd.2012.135.142Terminalia chebula Retz. Alloxan Induced Diabetic Rats]]>KannanV. Rajesh RajasekarG. Stalin RajeshP. BalasubramanianV. RameshN. SolomonE. King NivasD. ChandruS. 3201223The present study intended to evaluate the beneficiary effects of ethanolic extract of Terminalia chebula Retz. fruits (EETC) by using alloxan-monohydrate induced diabetic control by using Wistar Albino rats. The toxicity study was performed on aliquot doses of EETC (100 to 500 mg kg-1 b.wt.) and predetermined the LD50 value on 30 days evaluation; also the behavioral changes, symptoms and mortality have been checked, the EETC showed the nil toxicity up to 500 mg kg-1 b.wt. The effect of EETC (200 mg kg-1 b.wt.) was compared with the glibenclamide (600 mg kg-1 b.wt.) that is often used as a standard drug and the anti-diabetic activity has been conducted for 30 days. After the completion of the study, animals were dissected through cervical dislocation and collected the blood, serum and pancreas. The collected samples were performed under parameters like biochemical and anti-oxidant enzymes related to diabetes such as, weight variation, blood glucose, plasma insulin, serum and liver protein, serum and liver cholesterol, serum and liver triglyceride, serum and liver phospholipids, SGOT (Serum Glutamate Oxaloacetic Transaminase), SGPT (Serum Glutamate Pyruvate Transaminase), ACP (Acid Phosphatase), ALP (Alkaline Phosphatase), GSH (Glutathione reductase), GPT (Glutamate Pyruvate Transaminase), GPX (Glutathione Peroxidase), CAT (Catalase) and histopathological sections of the pancreas, the above parameters calculated and showed that the significance at p<0.001 to 0.05. The histopathological changes caused after induction of alloxan showed the granular cytoplasm, dilatation, shrunken nuclei and inflammation, which were reduced after treatment of the EETC (200 mg kg-1 b.wt.). Excess proliferation of epithelium in the pancreas was observed in diabetic rats, which was reduced after administration of the EETC (200 mg kg-1 b.wt.). From the evaluation of the present study on EETC has been confirmed that having the pharmacological action against the diabetic condition, even though the mechanism of the action is unknown, also it can be used further molecular compound analysis and define the chemical to the action.]]>King, H., R.E. Aubert and W.H. Herman,19982114141431Garber,19981998pp: 1850-1854pp: 1850-1854WHO.,19801980Singh, R.P., B. Padmavathi and A.R. Rao,2000Adhatoda veisca (Justica adhatoda) leaf extract on the enzyme of xenobiotic metabolism, anti-oxidant status and lipid peroxidation in mice.]]>21399109Chopra, R., S.L. Nayar and I.C. Chopra,19561st Edn.,Perry, L.M.,1980pp: 80-81.pp: 80-81.Singh, C.,1990Terminalia chebula.]]>2923482350Barthakur, N.N. and N.P. Arnold,1991Chebulinic myrobalan (Terminalia chebula Retz.) and its potential as a food source.]]>40213219Sabu, M.C. and R. Kuttan,200281155160Saleem, A., M. Husheem, P. Harkonen and K. Pihalaja,2002Terminalia chebula Retz. fruit.]]>81327336Kaur, S., S. Arora, K. Kaur and S. Kumar,2002in vitro antimutagenic activity of Triphala-an Indian herbal drug.]]>40527534Ahn, M.J., C.Y. Kim, J.S. Lee, T.G. Kim and S.H. Kim et al.,2002Terminalia chebula and flavonol glycoside gallates from Euphorbia pekinensis.]]>68457459Afzalakhtar, M., M.H. Rahber-Bhatti and M. Aslam,1997Anthomonas campestris vp. Citri.]]>43149153Ragunathan, V. and N. Sulochana,1994Hibiscus vitifolius Linn. and its hypoglycaemic activity.]]>71705706Aruna, R.V., B. Ramesh and V.N. Kartha,199937399401Chigozie, I.J. and I.C. Chidinma,2012Sansevieria senegambica baker (Agavaceae) on alloxan-induced diabetic wistar rats.]]>24866Rhoads, R.K., Gokulananada and G.S. Tomat,19961996Priya, E.M., K.M. Gothandam and S. karthikeyan,2012Feronia limonia and Artocarpus heterophyllus in Streptozotocin induced diabetic rats.]]>74349Ahmad, M., F. Zaman, T. Sharif and C.M. Zabta,2008Aqueous methanolic extract of acacia nilotica pods in alloxan-induced diabetic rabbits.]]>352934Jothivel, N., S.P. Ponnusamy, M. Appachi, S. Singaravel and D. Rasilingam et al.,200753655663Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.J. Randall,1951193265275Ahmed, M.F., S.M. Kazim, S.S. Ghori, S.S. Mehjabeen, S.R. Ahmed, S.M. Ali and M. Ibrahim,2010Vinca rosea extracts in Alloxan-induced diabetic rats.]]>2010Selvan, V.T., L. Manikandan, S.G.P. Kumar, S.R.B.B. Kakoti and P. Gomathi et al., 2008 Artanema sesamoides in streptatozocin-induced diabetic rats. ]]>12533