Asian Journal of Clinical Nutrition1992-14702077-2033Asian Network for Scientific Information10.3923/ajcn.2017.44.50Keumala SariDina Zulkarnaini TalaZaimah LestariSri Vyatra HutagalungSunna Akbari GanieRatna 1201791Background: Women were found to be at particularly high risk vitamin D deficiency. High prevalence of vitamin D deficiency was reported
in tropical countries. Objective: This work aimed to investigate range level of 25(OH)D serum in women with single nucleotide
polymorphisms of Vitamin D Receptor (VDR) gene who lived in North Sumatera, Indonesia. Materials and Methods: Vitamin D levels were
determined in women displaying TaqI and BsmI single nucleotide polymorphic variants in the Vitamin D Receptor (VDR) gene.
A cross-sectional design was adopted and a total of 292 subjects were included over the period of four years (2012-2016). Sun exposure
duration, occupation, Vitamin D intake, physical activity level and body mass index were also recorded. Results: Serum vitamin D
concentrations were found to be deficient in 122, insufficient in 158 and sufficient in only 12 subjects, but none were in the standard
normal range for sunny countries (54-90 ng mL1). Moreover, all subjects were found to be heterozygous for TaqI and BsmI variants with
TC and AG genotype, respectively. Mean serum 25(OH)D levels fell in the range 20.8±6.4 ng mL1. The median was 21.2 ng mL1 and
the interquartile range was 16.45-24.59 ng mL1. Conclusion: Vitamin D deficiency/insufficiency was found to be common in healthy
women with TaqI and BsmI single nucleotide polymorphisms in the VDR gene and a normal range for 25(OH)D serum levels was posited.]]>Sari, D.K., H.A. Damanik, N.I. Lipoeto and Z. Lubis,20132013Keumala, S.D., D.H. Alrasyid, L. Nurindrawaty and L. Zulkifli,2014206370Khor, G.L., W.S.S. Chee, Z.M. Shariff, B.K. Poh, M. Arumugam, J.A. Rahman and H.E. Theobald,20112011Liel, Y., E. Ulmer, J. Shary, B.W. Hollis and N.H. Bell,198843199201Wortsman, J., L.Y. Matsuoka, T.C. Chen, Z. Lu and M.F. Holick,200072690693Vupputuri, M.R., R. Goswami, N. Gupta, D. Ray, N. Tandon and N. Kumar,20068314111419Engelsen, O., M. Brustad, L. Aksnes and E. Lund,20058112871290Ferrarezi, D.A.F., N. Bellili-Munoz, C. Nicolau, N. Cheurfa and I.C. Guazzelli et al.,20126114131421Tangpricha, V., E.N. Pearce, T.C. Chen and M.F. Holick,2002112659662Al-Daghri, N.M., O. Al-Attas, M.S. Alokail, K.M. Alkharfy and H.M. Draz et al.,201218813251332Holick, M.F.,20051352739S2748SGrant, W.B. and M.F. Holick,20051094111Holick, M.F.,2007357266281Harinarayan, C.V.,200516397402Roy, D.K., J.L. Berry, S.R. Pye, J.E. Adam, C.M. Swarbrick and Y. King,200740200204Holick, M.F.,200829361368Chiu, K.C., A. Chu, V.L. Go and M.F. Saad,200479820825Renzaho, A.M.N., J.A. Halliday and C. Nowson,201127868879Alvarez, J.A. and A. Ashraf,20102010Al-Othman, A., S. Al-Musharaf, N. Al-Daghri, S. Krishnaswamy and D.S. Yusuf et al.,20122012Hollis, B.W.,2005135317322Jain, R., P.R. von Hurst, W. Stonehouse, D.R. Love, C.M. Higgins and J. Coad,201261293301McKinney, K., C.R. Breitkopf and A.B. Berenson,200869535541Kull, M., R. Kallikorm and M. Lember,200939256258Goldner, W.S., J.A. Stoner, J. Thompson, K. Taylor, L. Larson, J. Erickson and C. McBride,200818145150Chapuy, M.C., R. Pamphile, E. Paris, C. Kempf and M. Schlichting et al.,20023 supplementation in elderly women: Confirmation of reversal of secondary hyperparathyroidism and hip fracture risk: The Decalyos II study.]]>13257264