Asian Journal of Cell Biology1814-00682152-3517Academic Journals Inc.10.3923/ajcb.2011.81.88Catharanthus roseus)]]>AdekomiD.A. IbiyeyeR.Y. PopoolaA.N. OyesomiO.T. 2201162This study was elucidated in order to evaluate the effects of ethanolic leaf extract of Madagascar periwinkle (Catharanthus roseus) (documented for its hypoglycemic effects on experimental animals) on the activities of glucose-6-phosphate dehydrogenase and lactate dehydrogenase on the kidney, liver and pancreas of adult Wistar rats. Thirty-two rats (of the first filial generation) of both sexes (Albino, Wistar) were used. Animals weighed 214-232 g and were about 7-13 weeks old. The animals were divided into four groups designated as A, B, C and D of eight animals in each. Groups A, B and C were administered with 400 mg kg-1, 300 mg kg-1 and 200 mg kg-1 b.wt. of the plant extract respectively while the control group was administered with equal volume of phosphate buffered saline orally for 21 days. At termination of study, it was observed that there was significant increase in glucose-6-phosphate dehydrogenase and significant decrease in lactate dehydrogenase enzyme activities in the administered groups. The results obtained from this study suggested that the leaf extract of Madagascar periwinkle (Catharanthus roseus) consumed for its hypoglycemic effects, alters carbohydrate metabolism in the kidney, liver and pancreas and has no deleterious effect on the organs of study in Wistar rats. Further studies should be done in order to know if such effects seen in Wistar rats may by extension be seen in man.]]>Adekomi, D.A.,2010Catharanthus roseus) enhances kidney and liver functions in Wistar rats.]]>6245254Beutler, E., T. Vulliamy and L. Luzzatto,1996224956Butt, A.A., S. Michaels, D. Greer, R. Clark, P. Kissinger and D.H. Martin,200212317321Chabner, B.A. and D.L. Longo,20054th Edn.,pp: 879pp: 879Chattopadhyay, R.R., S.K. Sarkar, S. Ganguly, R.N. Banerjee and T.K. Basu,1991Vinca rosea Linn.]]>35145151Chattopadhyay, R.R., R.N. Banerjee, S.K. Sarkar, S. Ganguly and T.K. Basu,1992Vinca rosea Linn in experimental animals.]]>36291292Chattopadhyay, R.R.,199967367372David, A.J., A.G. Adefolaju, B.U. Enaibe, M.S. Ajao and E.A. Caxton-Martins,2009Azadirachta indica) leaves.]]>813101313Dhanasekaran, J.J. and M. Ganapathy,2011Cassia auriculata L. leaf extract on carbon tetrachloride intoxicated liver damage in wister albino rats.]]>6104112Elgorashi, E.E., J.L.S. Taylor, A. Maes, J. Van Staden, N. De Kimpe and L. Verschaeve,2003143195207Hasani-Ranjbar, S., N. Nayebi, B. Larijani and M. Abdollahi,2010Teucrium species; from anti-oxidant to anti-diabetic effects.]]>6315325Hsia, S.H., M. Bazargan and M.B. Davidson,20045311661173Iweala, E.E.J. and C.U. Okeke,2005Catharanthus roseus (Linn) g. apocynaceae (Madagascar periwinkle) and chlorpropamide (diabenese) on alloxan-induced diabetic rats.]]>17149156Iweala, E.E.J. and F.D. Oludare,2011Spondias mombin Linn. and Parinari polyandra benth. Seeds ethanolic extracts in alloxan-induced diabetic rats.]]>6101112Jaya, A., P. Shanthi and P. Sachdanandam,2010Semecarpus anacardium in streptozotocin induced diabetic rats.]]>6435443Joseph, B. and D. Jini,20115352376Gaston, K.J. and J.I. Spicer,20042nd Edn.,pp: 191pp: 191Kind, P.R.N. and E.J. King,19547322326King, E.J. and K.A. Jegatheesan,1959128589Kletzien, R.F., P.K. Harris and L.A. Foellmi,19948174181Mostofa, M., M.E. Choudhury, M.A. Hossain, M.Z. Islam, M.S. Islam and M.H. Sumon,2007Catharanthus roseus, Azadirachta indica, Allium sativum and Glibenclamide in experimentally diabetic rats.]]>599102National Institute of Health,1985Hall, N.,1978pp: 160pp: 160Patrick-Iwuanyanwu, K.C. and M.O. Wegwu,20084)-induced liver damage in rats by Acanthus montanus.]]>3213220Saidu, Y., L.S. Bilbis, M. Lawal, S.A. Isezuo, S.W. Hassan and A.Y. Abbas,2007Albizzia chevalieri harms (Leguminosae).]]>2224236Salvemini, F., A. Franze, A. Iervolino, S. Filosa, S. Salzano and M.V. Ursini,199927427502757Singh, S.N., P. Vats, S. Suri, R. Shyam, M.M.L. Kumria, S. Ranganathan and K. Sridharan,2001Catharanthus roseus on enzymic activities in streptozotocin induced diabetic rats.]]>76269277Xu, Y., B.W. Osborne and R.C. Stanton,2005289F1040F1047Zhang, Z., K. Apse, J. Pang and R.C. Stanton,20002754004240047Zheng, W. and S.Y. Wang,20014951655170