Asian Journal of Cell Biology1814-00682152-3517Academic Journals Inc.10.3923/ajcb.2008.1.21E. AbdelmeguidNabila S. HamedSherifa A. AhmedEglal 1200831The main purpose of the present study was to determine the mechanism
by which captopril induces its toxic effect. The study also aimed to determine
whether furosemide (a diuretic drug) inhibits or promotes the side effects
produced by captopril administration. Two dose levels of captopril were
used; low dose (0.01 mg for six days a week, for four weeks) and a high
dose (0.23 mg for six days a week, for four weeks). Captopril produced
changes in behavioral and external features, changes in the cytological
picture of liver and kidney and damage of the cardiac muscle fibers. These
changes were found to be statistically proportional to the dose used.
Another two groups were studied. One of these groups received the low
captopril dose only with furosemide (0.02 mg) and the other received the
high captopril dose only with the same furosemide dose for the same period
of treatment. Furosemide (0.02 mg) inhibited the decrease in the body
weight loss induced by the admission of captopril alone (at both dose
levels). It also decreased the mortality rate in mice, but it failed to
inhibit the cyto-pathological alterations induced by captopril administration.
Despite of the observed damaging effect of the drugs under investigation,
they are commonly used as antihypertensive drugs.]]>Ahmed, A.M., M.S. Hassan, A.A. ElHawary, K.A. Khalil and A.A. Serwah,199212465478Alon, U.S., R.A. Kaplan, L.L. Gratny and M.A. Nichols,199610191194Araki, M., T. Kanda, S. Imai, T. Suzuki, K. Murata and I. Kobayashi,1995266165Bereiter-Hahn, J.,1990122163Bereiter-Hahn, J. and M. Vöth,199427198219Carnevali, M.D.C. and A. Saita,19751975Case, D.B., S.A. Attas, J.A. Mouradian, R.A. Fishman, R.L. Sherman and J.H. Laragh,1980244346349Cavanagh, E.M., C.G. Fraga, L. Ferder and F. Inserra,1997272R514R518Cohen, E.P., A. Molteni, P. Hill, B.L. Fish and W.F. Ward et al.,199675349360Cook, M.L., L. Osvaldo, J.D. Jackson and H. Latta,196514623623Friberg, P., B. Sundelin, S.O. Bohman, A. Bobik and H. Nilsson et al.,199445485492Ghadially, F.N.,19974th Edn.,Hu, Z., M. Billingham, M. Tuck and B.B. Hoffman,199015210215Hufnagle, K., S.N. Khan, D. Penn, A. Cacciarelli and P. Williams,198270360363Khattab, M.M., A. Mostafa and O. Al-Shabanah,200528243250Kleinman, H.K. and M.L. Ponce,199698599599Klouchek, E. and A. Popov,1989284750Kobayashi, I.,199526561Leor, J., N. Bloom, D. Hasdai, Z. Ovadia and A. Battler,199445717724Lopez, R., C. Toboada, C. Rivas and S. Miguel,1996528994Luderer, J.R., A.C. Schoolwerth, R.A. Sinicrope, J.O. Ballard, D.P. Lookinbill and A.H. Hayes,198171493496Mitchell, J.R., W.Z. Potter, J.R. Hinson and D.J. Jollow,1974251508511Mitchell, J.R., W.L. Nelson, W.Z. Potter, H.A. Sasame and D.J. Jollow,19761994152More, R.H. and C.N. Crowson,1955606363Motwani, J.G., M.K. Fenwick, J.J. Morton and A.D. Struthers,199286439445Mougenot, N., R. Bos, A. Mediani and P. Lechat,200519457464 Ponraj, D. and P. Gopalakrishnakone,1997Pseudoechis australis snake myotoxin.]]>5119561969Powers, E.R., K.S. Bannerman, J. Stone, D.S. Reison and E.L. Escala et al.,198210412031210Rahmat, J., R.L. Gelfand, M.G. Gelfand, J.F. Winchester, G.E. Schreiner and H.J. Zimmerman,19851025056Sakr, A.A.,195518209219Shearlock, K.T. and B.C. Sturgill,198325023432345Squadrito, F., G. Macchiarelli, G. Stantoro, V. Arcoraci and G.R. Trimarchi et al.,19927223229Sultana, N., M.S. Arayne and R. Quraish,2007In vitro interactions of captopril with H2-receptor antagonists.]]>20132139Takase, K., T. Ikuse, H. Aono and A. Okahara,1995451518Vulpis, V., L. Rocali, M. Bertossi, B. Nico and T. Seccia et al.,1994841424Vulpis, V., T.M. Seccia, B. Nico, S. Ricci, L. Roncali and A. Pirrelli,199532375381Wight, D.G.D.,19821982