Asian Journal of Biological Sciences1996-3351xxxx-xxxxScience International10.3923/ajbs.2020.9.15OkpashiVictor Eshu BayimBayim Peter-Robert Obi-AbangMagdalene 12020131Background and Objectives: Diagnosing the onset of prostate cancer before the manifestation of symptoms is the challenge in detecting diseases.For intervention on the risk of cancer, this investigation assayed the in vitro estrogen elevation in men’s population, by quantifying free Oestradiol and sex hormone-binding globulin level of selected men in Eket-Nigeria. Materials and Methods: A 197 men’s subjects were selected using a simplified sample size formula. Blood serum samples were prepared from the blood collected from the men’s donors. The assay was carried out using estrogen (E2) and sex hormone binding globulin (SHBG), enzymes linked immunosorbent assay (ELISA) technique. The ratio of SHBG to E2 was calculated to get free oestradiol. Results: A 28 of 197 men have elevated E2 beyond the recommended reference range 15-60 pg mL1. This accounted for 14.21% of 28/197 men with elevated free estrogen. Conclusion: Comparing these figures with our control reference community where there was a low level of E2, one can infer that the men of Eket pose a risk of prostate cancer due to elevated E2. This implied that elevated testosterone is aromatized to estrogen by aromatase. Therefore, men of Eket should receive anti-estrogen therapy to reduce the risk of prostate cancer.]]>Okpashi, V.E., B.C. Obi, I. Okagu and P.O. Okoroafor,20182018Sathishkumar, K., R. Elkins, G.D.V. Hankins, H. Gao, C. Yallampalli,20182018Bosland, M.C.,20057S4S10Suzuki, K., H. Nakazato, H. Matsui, H. Koike and H. Okugi et al.,2003CYP19, catechol‐O‐methyltransferase are associated with familial prostate carcinoma risk in a Japanese population.]]>9814111416Tanaka, Y., M. Sasaki, M. Kaneuchi, H. Shiina, M. Igawa and R. Dahiya,200337202208Cancel-Tassin, G., A. Latil, F. Rousseau, P. Mangin and E. Bottius et al.,200344487490IARC.,19921992pp: 399-530pp: 399-530IARC.,1999Vol. 72,Nelles, J.L., W.Y. Hu and G.S. Prins,20116437451Barrett-Connor, E., C. Garland, J.B. McPhillips, K.T. Khaw and D.L. Wingard,199050169173Modugno, F., J.L. Weissfeld, D.L. Trump, J.M. Zmuda, P. Shea, J.A. Cauley and R.E. Ferrell,2001730923096Heinlein, C.A. and C. Chang,200425276308Gann, P.H., C.H. Hennekens, J. Ma, C. Longcope and M.J. Stampfer,19968811181126Selvin, E., M. Feinleib, L. Zhang, S. Rohrmann and N. Rifai et al.,200730234238Prins, G.S., L. Birch, W.Y. Tang and S.M. Ho,200723374382Palmer, J.R., L.A. Wise, E.E. Hatch, R. Troisi and L. Titus-Ernstoff et al.,20061515091514Titus-Ernstoff, L., E.E. Hatch, R.N. Hoover, J. Palmer and E.R. Greenberget al.,200184126133Driscoll, S.G. and S.H. Taylor,198056537542Ekbom, A., J. Wuu, H.O. Adami, C.M. Lu, P. Lagiou, D. Trichopoulos and C.C. Hsieh,20009221223Usoro, A.J., A.S. Obort, I.S. Ekaidem, O.E. Akaiso, A.E.Udoh and O. Akinloye,2015305965Swedenborg, E., J. Rüegg, S. Mäkelä and I. Pongratz,200943110Gore, A.C.,201091627Elmlinger, M.W., W. Kühnel and M.B. Ranke,20024011511160Gore, A.C.,200829358374Li, X., S. Zhang and S. Safe,200698122132Risbridger, G.P., S.J. Ellem and S.J. McPherson,200739183188