Asian Journal of Biological Sciences1996-3351xxxx-xxxxScience International10.3923/ajbs.2019.173.179Centella asiatica and Curcuma longa in Rats]]>HasimunPatonah MulyaniYani SulaemanAgus Embas SaraswatiDewa Ayu 22019122Background and Objectives: Hypertension is characterized by an increase in systolic and or diastolic blood pressure. Arterial stiffness is an independent cardiovascular risk factor in hypertensive patients. Increasing arterial stiffness correlates with hypertension progression. This study aimed to determine anti-hypertensive activity and reducing arterial stiffness, combination of Centella asiatica and Curcuma longa, in 25% fructose-induced hypertensive animal models in drinking water and high-fat diet. Materials and Methods: This study was conducted on male Wistar rats with 3 methods: Diuretic test, anti-hypertensive test and arterial stiffness test by non-invasive method. Two doses combination of Centella asiatica and Curcuma longa were at 3.6 and 1.8 g kg1 in juice preparation, compared to furosemide (diuretic test), captopril (anti-hypertensive test). Parameters measured were urine volume, systolic and diastolic blood pressure and Pulse Wave Velocity (PWV). Results: Combination of Centella asiatica and Curcuma longa in juice preparation, increased urine output (diuretic), decreased systolic and diastolic blood pressure and improved arterial stiffness (p<0.05) compared to the control group. Conclusion: Combination of Centella asiatica and Curcuma longa in juice preparation has anti-hypertensive activity and improved arterial stiffness.]]>James, P.A., S. Oparil, B.L. Carter, W.C. Cushman and C. Dennison-Himmelfarb et al.,2014311507520Riley, L., H. Gouda and M. Cowan,2017Pages: 231Pages: 231Kementerian Kesehatan RI,2013Blacher, J., R. Asmar, S. Djane, G.M. London and M.E. Safar,19993311111117Niiranen, T.J., B. Kalesan, N.M. Hamburg, E.J. Benjamin, G.F. Mitchell and R.S. Vasan,20162016Sharman, J.E., P. Boutouyrie and S. Laurent,20172017Mitchell, G.F., S.J. Hwang, R.S. Vasan, M.G. Larson and M.J. Pencina et al.,2010121505511Sukandar, E.Y., H. Permana, I.K. Adnyana, J.I. Sigit, R.A. Ilyas, P. Hasimun and D. Mardiyah,2010Curcuma longa L.) and garlic (Allium sativum L.) extracts as antihyperglycemic and antihyperlipidemic agent in type-2 diabetes-dyslipidemia patients.]]>6456463Akinyemi, A.J., G.R. Thome, V.M. Morsch, N.B. Bottari and J. Baldissarelli et al.,201682612620Campbell, M.S. and B.S. Fleenor,20172017Erdos, B., N. Kirichenko, M. Whidden, B. Basgut and M. Woods et al.,2011301H164H172Lipschitz, W.L., Z. Hadidian and A. Kerpesar,19437997110Zakaria, H. and P. Hasimun,20172017pp: 9598Klein, A.V. and H. Kiat,201533912920Sainz, N., J. Barrenetxe, M.J. Moreno-Aliaga and J.A. Martinez,2015643546Lozano, I., R. van der Werf, W. Bietiger, E. Seyfritz and C. Peronet et al.,20162016Pakdeechote, P., S. Bunbupha, U. Kukongviriyapan, P. Prachaney, W. Khrisanapant and V. Kukongviriyapan,20146355370Kelany, M.E., T.M. Hakami and A.H. Omar,201695140150Elkhamisy, A.E.,2015100108Sangartit, W., U. Kukongviriyapan, W. Donpunha, P. Pakdeechote, V. Kukongviriyapan, P. Surawattanawan and S.E. Greenwald,20142014Fong, L.Y., C.T. Ng, Y.K. Yong, M.N. Hakim and Z. Ahmad,20182018