Asian Journal of Biological Sciences1996-3351xxxx-xxxxScience International10.3923/ajbs.2011.540.547Gongronema latifolium on Serum Kidney and Liver Biomarkers of Normal Male Rats]]>SpencerC.O. Nwangwu J. Josiah Sunday TeslimatE. Abubakar KazeemO. Ajeigbe EguagieO. Osakwe AkinolaA. Akintola 7201147In the south eastern part of Nigeria the use of Gongronema latifolium leaves
as part of food and herbal medicine has been on the increase. This study was
undertaken to compare the effects of aqueous and ethanolic extracts from Gongronema
latifolium (Asclepiadaceae) leaves on some kidney and liver biomarkers of
normal male rats. The animals were distributed into two sets of two groups.
Each set had its control administered normal saline while the other groups in
the two sets were administered 200 mg kg-1 of ethanolic and aqueous
leaf extracts. The extracts were administered in normal saline for three weeks.
The serum Total Protein (TP), Alkaline Phosphatase (ALP), Alanine Transaminase
(ALT), Aspartate Transaminase (AST), Albumin (ALB) and Bilirubin levels were
evaluated after every seven days. Kidney biomarkers were also evaluated in the
same vein by determining the level of serum urea, creatinine, sodium ions (Na+)
and chloride ions (Cl¯) in serum. The aqueous extract showed little or
no effect on the liver and kidney biomarkers. The hepatotoxic nature of the
ethanolic extract was shown by the significant increases in levels of ALT, AST,
Bilirubin and ALP which was buttressed by the significant reduction in TP and
ALB. The Urea and Creatinine levels increased significantly with prolonged administration.
This pattern was also observed with Cl¯ and Na+ which increased
from the 14th day suggestive of kidney impairment. In view of these results,
it was suggestive that the ethanolic extract from Gongronema latifolium
leaves had hepatotxic and nephrotoxic potentials.]]>Abdulazeez, A.M., C.A. Awasum, Y.S. Dogo and P.N. Abiayi,2010Peristrophe bicalyculata on blood pressure, kidney and liver functions of two kidney one clip (2K1C) hypertensive rats.]]>1101107Afolayan, A.J. and M.T. Yakubu,2009Bulbine natalensis baker stem extract on the functional indices and histology of the liver and kidney of male Wistar rats.]]>12814820Akuodor, G.C., M.S. Idris-Usman, C.C. Mbah, U.A. Megwas and J.L. Akpan et al.,2010Gongronema latifolium in rodents.]]>923162321Ruot, B., D. Breuille, F. Rambourdin, G. Bayle, P. Capitan and C. Obled,2000279E244E251Burns, D., W.F. Renolds, G. Buchanan, P.B. Reese and R.G. Enriquiez,2000387488493Baumann, E., G. Stoya, A. Volkner, W. Richter, C. Lemke and W. Linss,20001022135Edet, E.E., I.J. Atangwho, M.I. Akpanabiatu, T.E. Edet, F.E. Uboh and E. David-Oku,2011Gongronema latifolium leaf extract on some liver enzymes and protein levels in diabetic and non-diabetic rats.]]>1104107Emeka, E.J.I. and O. Obidoa,2009Gongronema latifolium Benth. on some biochemical and histological parameters in male albino rats.]]>9859865Jalalpure, S.S., M.B. Patil, N.S. Prakash, K. Hemalata and F.V. Manvi,2003Piper longum L.]]>65363366Kang, S.K., W. Kim and M.S. Oh,2002921417Latunde-Dada, G.O.,199053355361De Madureira, M.D.C., A.P. Martins, M. Gomes, J. Paiva, AP. da Cunha and V. do Rosario,2002812329Masaba, S.C.,2000Vernonia amygdalina Del (Compositae).]]>94694695Mensah, J.K., R.I. Okoli, J.O. Ohaju-Obodo and K. Eifediyi,2008723042309Morebise, O., M.A. Fafunso, J.M. Makinde, O.A. Olajide and E.O. Awe,2002Gongronema latifolium.]]>167577Nuhu, A.A. and R. Aliyu,2008Cassia occidentalis aqueous leaf extract on biochemical markers of tissue damage in rats.]]>711371142Nwangwu, S.C., F. Ike, M. Olley, J.M. Oke and E. Uhunmwangho et al.,2009Landolphia owariensis on the serum lipid profile of rats.]]>3136139Nwangwu, S.C.O., U.C. Nwangwu, S.J. Josiah and C. Ezenduka,2010Gongronema latifolium on normal male rats.]]>1795729583Nwaogu, L.A., C.S. Alisi, C.O. Ibegbulem and C.U. Igwe,2007Landolphia owariensis leaf.]]>6890893Nwinyi, O.C., N.S. Chinedu and O.O. Ajani,2008Pisidium guajava and Gongronema latifolium.]]>2189192Ogbebor, N.O., A.T. Adekunle and D.A. Enobakhare,2007Colletrotrichum gloeosporioides (Penz) Sac. causal organism of rubber (Hevea brasiliensis Muell. Arg.) leaf spot using plant extracts.]]>6213218Omotuyi, I.O., S.C. Nwangwu, O.T. Okugbo, O.T. Okoye, G.C. Ojieh and D.M. Wogu20082107110Saba, A.B., O.A. Oridupa and S.O. Ofuegbe,2009Lagenaria breviflora Robert.]]>3758762Saraswat, B., P.K. Visen G.K. Patnaik and B.N. Dhawan,1993Picrorhiza kurrooa, against carbon tetrachloride induced cholestasis.]]>31316318Tona, L., R.K. Cimanga, K. Mesia, C.T. Musamba and T. de Bruyne et al.,2004In vitro antiplasmodial activity of extracts and fractions from seven medicinal plants used in the democratic republic of Congo. ]]>932732Uboh, F.E., I.E. Okon and M.B. Ekong,2010Psidium guajava leaves on liver enzymes, histological integrity and hematological indices in rats.]]>33238Karim, A., M.N. Sohail, S. Munir and S. Sattar,20117419439Eleyinmi, A.F.,2007Gongronema latifolium.]]>8352358Ugochukwu, N.H., N.E. Babady, M. Cobourne and S.R. Gasset,2003Gongronema latifolium extracts on serum lipid profile and oxidative stress in hepatocytes of diabetic rats.]]>2815