American Journal of Biochemistry and Molecular Biology2150-42102150-4253Academic Journals Inc.10.3923/ajbmb.2016.60.66ω-nitro-l-arginine-methylester-induced Hypertensive Rats]]>RamanathanVeerappan RajagopalSenthilkumar 2201662Background: It is investigated to deduct the action of chrysin on the cardiovascular risk of Nω-nitro-L-arginine methyl ester
(L-NAME)-induced hypertensive rats. The L-NAME is a non-specific Nitric Oxide (NO) synthase inhibitor, commonly used for the induction
of NO-deficient hypertension. Materials and Methods: The L-NAME (40 mg kg1 b.wt.) was dissolved in drinking water and was given
to rats at an interval of 24 h for 8 weeks. Chrysin were administered orally once in a day in the morning for 4 weeks. The compound
was suspended in 2% dimethyl sulfoxide solution and fed by incubation. After 8th week morning the animals were sacrificed by cervical
dislocation and done with lipid profiles parameters. Results: Administration of L-NAME significantly increased the mean arterial pressure and heart rate compared to control rats, while treatment with chrysin significantly reduced the mean arterial pressure and heart rate
compared to hypertensive rats. When L-NAME-induced hypertensive rats compared with the control, an extend sign were seen in the
factors such as the concentrations of plasma, tissue (liver and kidney) lipids, lipoproteins and hepatic marker enzymes and a decrement
were noted in the concentration of high-density lipoprotein cholesterol. A recent of hyperlipidemia resulted from oral prescription of
chrysin. Conclusion: Thus, chrysin gives protection against hyperlipidemic and hepatic damage in rats with L-NAME induced hypertension.]]>Mittal, B.V. and A.K. Singh,201055590598Vasdev, S., V.D. Gill and P.K. Singal,200611206216Ribeiro, M.O., E. Antunes, G. de Nucci, S.M. Lovisolo and R. Zatz,199220298303Bernatova, I., O. Pechanova and F. Kristek,1999G-nitro-L-arginine methyl ester treatment.]]>8199106Cayatte, A.J., J.J. Palacino, K. Horten and R.A. Cohen,199414753759Naruse, K., K. Shimizu, M. Muramatsu, Y. Toki and Y. Miyazaki et al.,199414746752Aneja, A., F. El-Atat, S.I. McFarlane and J.R. Sowers,200459169205Jayakumar, T., P.A. Thomas and P. Geraldine,2009In-vitro antioxidant activities of an ethanolic extract of the oyster mushroom, Pleurotus ostreatus.]]>10228234Williams, C.A., J.B. Harborne, M. Newman, J. Greenham and J. Eagles,1997Pelargonium.]]>4613491353Veerappan, R. and S. Rajagopal,201552027Pearce, F.L., A.D. Befus and J. Bienenstock,198473819823Fishkin, R.J. and J.T. Winslow,1997132335341Habtemariam, S.,199760775778Kao, Y.C., C. Zhou, M. Sherman, C.A. Laughton and S. Chen,19981068592Wolfman, C., H. Viola, A. Paladini, F. Dajas and J.H. Medina,1994Passiflora coerulea.]]>4714Malarvili, T. and R. Veerappan,20144112117Kubo, I., I. Kinsy-Hori, S.K. Chaudari, Y. Kubo, Y. Sandoz and T. Ogura,2000Heterotheca inuloides: Tyrosinase inhibitory activity and structural criteria.]]>817491755Joshi, S.C., L. Strauss, S. Makela and R. Santti,19992235238Wang, C. and M.S. Kurzer,19983190100Rice-Evans, C.A. and L. Packer,1997pp: 179-197pp: 179-197Larget, R., B. Lockhartb, P. Renardc and M.A. Largeron,2000in vitro.]]>10835838Ramanathan, V. and M. Thekkumalai,201445863Zlatkis, K., B. Zak and A.J. Boyle,195341486492Foster, L.B. and R.T. Dunn,197319338340Falholt, K., B. Lund and W. Falholt,197346105111Zilversmit, D.B., A.K. Davis, B. Memphis and N. Tenn,195035155160Nerurkar, S.V. and S.P. Taskar,1985318994Reitman, S. and S. Frankel,1957285663Kind, P.R.N. and E.J. King,19547322326Mattson, D.L.,1998274R564R570Attia, D.M., A.M.G. Verhagen, E.S.G. Stroes, E.E. van Faassen and H.J. Grone et al.,20011225852593Friedewald, W.T., R.I. Levy and D.S. Fredrickson,197218499502Chiang, J.Y.L.,200223443463Fossati, P. and L. Prencipe,19822820772080Matsuda, Y., K. Hirata, N. Inoue, M. Suematsu, S. Kawashima, H. Akita and M. Yokoyama,19937211031109Senna, S.M., R.B. Moraes, M.F.R. Bravo, R.R. Oliveira and G.C. Miotto et al.,19984610071018Jeppesen, J.O., H.O. Hein, P. Suadicani and F. Gyntelberg,19989710291036Iacono, J.M., M.W. Marshall, R.M. Dougherty, M.A. Wheeler, J.F. Mackin and J.J. Canary,19754426443Leiba, A., A. Vald, E. Peleg, A. Shamiss and E. Grossman,200521462466Postic, C. and J. Girard,2008de novo fatty acid synthesis to hepatic steatosis and insulin resistance: Lessons from genetically engineered mice.]]>118829838Kumai, T., S. Oonuma, N. Matsumoto, Y. Takeba and R. Taniguchi et al.,20047421292142Virchow, R.,18601860pp: 324-366pp: 324-366Jiang, T., Z. Wang, G. Proctor, S. Moskowitz and S.E. Liebman et al.,20052803231732325Veerappan, R.M., T. Malarvili and G. Archunan,201441722Hoetzel, A., A. Welle, R. Schmidt, T. Loop and M. Humar et al.,2008186169Loria, P., A. Lonardo, L. Carulli, A.M. Verrone and M. Ricchi et al.,2005223136Zimmerman, H.J. and L.B. Seef,19701970pp: 1-38pp: 1-38Yadav, N.P. and V.K. Dixit,2003Kalanchoe pinnata Pers.]]>86197202