American Journal of Biochemistry and Molecular Biology2150-42102150-4253Academic Journals Inc.10.3923/ajbmb.2014.143.154Corchorus olitorius L., in Carbon Tetrachloride-Induced Liver Damage in Male Wistar Rats]]>IwealaE.E.J. OkedoyinA.G. 4201444Carbon tetrachloride (CCl4) has been extensively used in experimental models to demonstrate its hepatotoxic potential. Humans are often exposed to it where it is used in petrol additives, refrigerants, catalyst in polymer formation and in pesticides. In this study, the effect of leaves of Corchorus olitorius L. in CCl4-induced liver damage in male wistar rats was assessed using alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), plasma total protein, superoxide dismutase (SOD), catalase (CAT), glutathione-s-transferase (GST), reduced glutathione (GSH), Packed Cell Volume (PCV), hemoglobin (Hb) and White Blood Cell (WBC) as well as histological assay. Thirty five male wistar rats distributed into seven groups of five rats each were used in this study. The 1 mL kg-1 body weight of CCl4 was administered orally thrice in a week to hepatotoxic groups. Animals in all the groups were either fed control diet or C. olitorius-supplemented diets (COSD). It was observed from the result of this study that exposure to CCl4 and Corchorus olitorius L., produced a significant increase (p<0.05) in ALP activity and plasma total protein in some groups, no significant change (p>0.05) in AST, ALP and SOD activities and a significant decrease (p<0.05) in GST and catalase activities in the non-hepatotoxic groups while GSH increased significantly in all the groups. PCV, Hb and WBC count were not significantly different (p>0.05) and microscopic examination showed severe histological damage in hepatotoxic groups fed with C. olitorius-supplemented diet. These observations indicate that regular consumption of unprocessed C. olitorius L., may further enhance the hepatotoxic potential of CCl4 in humans.]]>Ahn, J., S. Nowell, S.E. McCann, J. Yu and L. Carter et al.,20061512171222Beers, Jr. R.F. and I.W. Sizer,1952195133140Beutler, E., O. Duron and B.M. Kelly,196361882888Chan, T.Y.K.,2011200107108Chen, Y., H. Wei, R. Sun, Z. Dong, J. Zhang and Z. Tian,200746706715Lewis, S.M., B.J. Bain, I. Bates and J. Dacie,20019th Edn.,Pages: 633Pages: 633Demirkol, O., C. Adams and N. Ercal,20045281518154Dossus, L. and R. Kaaks,200822551571Dragsted, L.O., A. Pedersen, A. Hermetter, S. Basu and M. Hansen et al.,20047910601072Ellman, G.L.,1959827077Friedenreich, C.M.,200110287301Fujii, T., B.C. Fuchs, S. Yamada, G.Y. Lauwers and Y. Kulu et al.,20102010Galler, J.,1997455356Gornall, A.G., C.J. Bardawill and M.M. David,1949177751766Habig, W.H., M.J. Pabst and W.B. Jakoby,197424971307139Hodgson, E. and P.E. Levi,20042004pp: 263-269, 271-272pp: 263-269, 271-272Emeka, E.J.I. and O. Obidoa,2009Telfairia occidentalis-supplemented diet in rats.]]>811991203Jaeschke, H., G.J. Gores, A.I. Cederbaum, J.A. Hinson, D. Pessayre and J.J. Lemasters,200265166176Kruk, J.,20078325338Lampe, J.W., C. Chen, S. Li, J. Prunty and M.T. Grate et al.,2000S-transferases by botanically defined vegetable diets.]]>9787792Malhi, H., G.J. Gores and J.J. Lemasters,2006433144Musa, A. and E.O. Ogbadoyi,2012Corchorus olitorius (Jute Mallow).]]>2012Noonan, S.C. and G.P. Savage,199986474Oboh, G., A.O. Ademiluyi, A.J. Akinyemi, T. Henle, J.A. Saliu and U. Schwarzenbolz,2012Corchorus olitorius) on key enzyme linked to type 2 diabetes (α-amylase and α-glucosidase) and hypertension (angiotensin I converting) in vitro.]]>4450458O'Grady, J.,20002000pp: 30.1-30.20pp: 30.1-30.20Okon, E.U. and E.O. Akpanyung,20054352355Oyedeji, K.O. and A.F. Bolarinwa,2013Corchorus olitorius extract on haematological and plasma biochemical parameters in male albino rats.]]>36871Patel, T., L.R. Roberts, B.A. Jones and G.J. Gores,199818105114Reitman, S. and S. Frankel,1957285663Rice-Evans, C.A., J. Sampson, P.M. Bramley and D.E. Holloway,1997in vivo?]]>26381398Ron, D. and P. Walter,20078519529Saba, A.B., A.A. Oyagbemi and O.I. Azeez,2010Cnidoscolus aconitifolius in rats.]]>25139147Shaarawy, S.M., A.A. Tohamy, S.M. Elgendy, Z.Y.A. Elmageed and A. Bahnasy et al.,20095549557Shittu, L.A.J., M.A. Bankole, T. Ahmed, K. Aile and M.A. Akinsanya et al.,2006Sesame radiatum against some common pathogenic micro-organisms.]]>1108111Tietz, N.W., E.L. Prude and O. Sirgard-Anderson,19942nd Edn.,pp: 1354-1374pp: 1354-1374Wark, P.A., M.J.A.L. Grubben, W.H.M. Peters, F.M. Nagengast, E. Kampman, F.J. Kok and P.V. Veer,2004S-transferase.]]>2521352142Wright, P.J., P.D. Leathwood and D.T. Plummer,197242317327Ziglari, T. and A. Allameh,20132013pp: 267-286pp: 267-286Zou, G.L., X.F. Gui, X.L. Zhong and Y.F. Zhu,198647173