American Journal of Biochemistry and Molecular Biology2150-42102150-4253Academic Journals Inc.10.3923/ajbmb.2011.82.88In vivo Studies]]>IribhogbeO.I. AkpamuU. EmordiJ.E. AigbiremolenA. NwokeE.O. IdinojeB. 1201111The effect on electrolyte profile following oral administration of antioxidants (vitamin A, C and E supplements in early pregnancy was investigated using albino rats of the Wistar strain. Eighty-five female rats weighing between 255-300 g were used for the study. They were randomly assigned to three study groups having 5 sub groups with five animals each, a control and vehicle group with five animals each. After pregnancy has been confirmed, the control group was administered 1 mL of distilled water, vehicle group 1 mL of tween 80, while test groups 1, II and III received different doses of vitamin A, C and E, respectively via the intragastric route for 11 days. The administration of vitamin A, C and E in early pregnancy for 11 days produced insignificant changes in serum Na+ levels (p>0.05) and a significant increase in serum Ca2+ level. With the exception of vitamin C, vitamin A and E produce a significant increase in serum K+ and Cl¯ levels. Conclusively administration of vitamin A, C and E in early pregnancy cause no significant alteration in serum Na+ levels. However, care must be taken when vitamin A and E are administered with agents that elevate serum Ca2+ and K+ levels as this may pontentiate hypercalcemia and hyperkalemia, respectively in early pregnancy.]]>Bashiri, A., L. Neumann, E. Maymon and M. Katz,199563135138Bertoni-Freddari, C., C. Giuli, G. Lustyik and I. Zs.-Nagy,1981In vivo effects of vitamin E deficiency on the intracellular monovalent electrolyte concentrations in brain and liver of rat. An energy dispersive X-ray microanalytic study.]]>16169180Bjelakovic, G., D. Nikolova, L.L. Gluud, R.G. Simonetti and C. Gluud,200827176Brzozowska, A., J. Kaluza, K.T.B. Knoops and L.C.P.G.M. de Groot,200847131137Chalker, R. and C. Downer,1992Christian, P., G.L. Darmstadt, L. Wu, S.K. Khatry and S.C. LeClerq et al.,200893660664Czeizel, A.E.,199617416671667Eteng, M.U., H.A. Ibekwe, T.E. Amatey, B.J. Bassey, F.U. Uboh and D.U. Owu,2006211519Forsmo, S., S.K. Fjeldbo and A. Langhammer,2008167406411Guyton, A.C.,200611th Edn.,Hall, J.E., M.W. Brands and J.R. Henegar,199910S258S265Kamath, S.A.,200654269270Kaupilla, A., I. Huhtaniemi and O. Ylikorkala,1979116701671Massey, L.K., M. Liebman and S.A. Kynast-Gales,200513516731677Ovcharov, R. and S. Todorov,197413191195, (In Bulgarian)Ornstein, M., A. Einarson and G. Koren,1995916Penniston, K.L. and S.A. Tanumihardjo,200683191201Prasad, K.,20103356774Rath, M.W. and L.C. Pauling,19941994Rumbold, A., L. Duley, C.A. Crowther and R.R. Haslam,20082008Sahu, S., R. Abraham, R. Vedavalli and M. Daniel,200953365369Samborskaia, E.P. and T.D. Ferdman,1966629698, (In Russian)Seller, M.J.1966184657662Suleyman, P., B. Ekrem and K.S. Abdulkerim,20102010Soules, M.R., C.L.Jr. Hughes, J.A. Garsia, C.H. Livengood, M.R. Prystowsky and E. 3rd Alexander,198055696700Tsalev, D.L. and Z.K. Zaprianov,1984Vobecky, J.S., J. Vobecky, D. Shapcott, D. Cloutier, R. Lafond and R. Blanchard,197646291296Weigel, R.M. and M.M. Weigel,19899613121318Wilcox, A.J., D.D. Baird and C.R. Weinberg,199934017961799Wideman, G.L., G.H. Baird and O.T. Bolding,196488592595Abt, A.F. and C.D. Farmer,198311115551565