Asian Journal of Biochemistry1815-99231815-9931Academic Journals Inc.10.3923/ajb.2014.131.141In silico Study]]>UpgadeAkhilesh BhaskarAnusha KumarasamyP. 3201493Dengue fever is one of the most threatening epidemics of this era and there
is no targeted vaccine and therapy. The present study was designed to elucidate
the natural compounds as therapeutic targets for dengue virus. In this study,
it is proposed that target approach for dengue drug discovery based on natural
ligands obtained from plant extract of C. papaya. Nonstructural proteins
were retrieved from the protein data bank and natural compounds were drawn using
drawing tool, before docking. All of them were subjected to drug and absorption
distribution metabolism toxicity analysis which shows satisfying results which
leads to docking studies. Series of 8 compounds have been screened and docked
for binding energy prediction and on the basis of lowest binding energy, the
potential ligands like 2-Methoxy-4-vinylphenol, 9-Octadecyne and 9, 12, 15-Octadecatrienoic
acid, (Z, Z, Z) are recommended for further studies.]]>Ocloo, A., N.C. Nwokolo and N.T.K.D. Dayie,2012Carica papaya.]]>2399406Bhattacharjee, A. and D. Bhattacharjee,20113715723Salonen, A., T. Ahola and L. Kaariainen,2005285139173WHO,2009Pages: 147Pages: 147Gross, D.,20032003Erbel, P., N. Schiering, A. D'Arcy, M. Renatus and M. Kroemer et al.,200613372373Cheng, F., W. Li, Y. Zhou, J. Shen and Z. Wu et al.,20125230993105Solis, F.J. and R.J.B. Wets,198161930Dawkins, G., H. Hewitt, Y. Wint, P.C. Obiefuna and B. Wint,2003Carica papaya fruit on common wound organisms.]]>52290292Gubler, D., G. Kuno and L. Markoff,20072007pp: 1163-1252pp: 1163-1252Lipinski, C.A., F. Lombardo, B.W. Dominy and P.J. Feeney,199723325Murthy, H.M.K., S. Clum and R. Padmanabhan,199927455735580Cowan, M.M.,199912564582Gupta, N., S. Srivastava, A. Jain and U.C. Chaturvedi,2012136373390 Noble, C.G., Y.L. Chen, H. Dong, F. Gu and S.P. Lim et al.,201085450462Ayoola, P.B. and A. Adeyeye,2010Carica papaya (pawpaw) leaves.]]>5325328Saklani, A. and S.K. Kutty,200813161171Arakaki, T.L., N.X. Fang, D.P. Fairlie, P.R. Young and J.L. Martin,200225241247Bikadi, Z. and E. Hazai,20092009Halstead, S.B.,200853273291