Asian Journal of Biochemistry1815-99231815-9931Academic Journals Inc.10.3923/ajb.2011.240.251Garcinia gummi-gutta on Haematology and Plasma Biochemistry of Catfish Pangasianodon hypophthalmus]]>PrasadG. PriyankaG.L. 3201163A 45 day study was undertaken to evaluate the effect of dietary aqueous extract of Garcinia gummi-gutta in catfish, Pangasianodon hypophthalmus on growth performance, basic haematological and biochemical parameters. Fishes were randomly distributed in to glass aquaria at ten fish/tank in triplicate. Five diets (30% crude protein) containing varying levels of aqueous extracts of G. gummi-gutta at 0, 500, 1000, 2000 and 3000 mg kg-1 were prepared and fed to the fishes twice daily at 3% of their body weight. The results for each test group were compared statistically with those for the control. Analysis of the results showed a significant increase in erythrocytes, leucocytes, thrombocytes, haemoglobin, packed cell volume, mean corpuscular haemoglobin concentration, protein and high density lipid and significant decrease in weight gain, specific growth rate, glucose, total cholesterol, triglycerides and low density lipid. The increase in cellular immunological indicators such as RBC, WBC and thrombocytes in the experimental fish may be due to the increase in the levels of immunity which in turn could be due to the action of the extract present in the diets. The decrease in total cholesterol, triglycerides and LDL could be due to the action of the hydroxy citric acid present in the dried fruit rind of G. gummi-gutta which has a known hypolipidaemic property. This decline in LDL cholesterol is by reducing the endogenous synthesis of cholesterol and triglyceride due to the decreased production of acetyl COA. 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