Asian Journal of Biochemistry1815-99231815-9931Academic Journals Inc.10.3923/ajb.2008.308.3144 Induced Hepatic Damage in Rats]]>SamudramP. RajeshwariH. VasukiR. GeethaA. Sathiya MoorthiP. 5200835The combined hepatoprotective effect of Bi-Herbal Ethanolic
Extract (BHEE) pretreatment against carbon tetra chloride (CCl4)
induced hepatic damage in rats was investigated. Ethanolic extract from
the leaves of Melia azedarach and seeds of Piper longum
at a dose level of 50 mg kg-1 body weight was administered
orally daily once for 14 days, prior to the administration of 0.2 mL of
CCl4 kg-1 body weight for 7 days. The substantially
elevated serum marker enzymes such as Serum glutamic Oxaloacetic Transaminase
(SGOT), Serum Glutamic Pyruvic Transaminase (SGPT), Alkaline Phosphatase
(ALP), Acid Phosphatase (ACP), Lactatedehydrogenase (LDH), Gamma glutamyl
Transferase (γGT) and 5 Nucleotidase (5NT), due to CCl4
treatment were restored towards normalization in rats pretreated with
BHEE. The determination of liver weight and biochemical parameters such
as serum bilirubin and blood urea showed a remarkable decrease in rats
pre- treated with the BHEE when compared with those administered CCl4
alone. In addition BHEE significantly increased the total protein,
total cholesterol and triglyceride also towards normal levels. Silymarin
at a dose level of 50 mg kg-1 was used as a standard reference
also exhibited significant hepatoprotective activity against CCl4
induced hepatotoxicity. The results of this study strongly indicate
that BHEE has got a potent hepatoprotective action against CCl4 induced
hepatic damage in rats.]]>Alche, L.E., A.A. Barquero, N.A. San Juan and C.E. Coto,200216348352Bandyopadhyay, U., D. Das and R.K. Banerjee,199977658666Cavin, C., K. Mace, E.A. Offord and B. Schilter,2001Coffee diterpenes against aflatoxin B1-induced genotoxicity: Mechanisms in rat and human cells.]]>39549556Chatterjee, T.K.,20003rd Edn.,Pages: 135Pages: 135Chattopadhyay, R.R.,2003Azadirachta indica leaf extract: Part II.]]>89217219Fossati, P. and P. Lorenzo,19832820772080Gadgoli, C. and S.H. Mishra,1999Capparis spinosa.]]>66187192Ghosh, M.N.,19841st Edn.,pp: 153-157pp: 153-157Achliya, G.S., S.G. Wadodkar and A.K. Dorle,200490229232Guido, S. and J. David,1998piperine on the pharmacokinetics of Curcumin in animals and human volunteers.]]>64353356Rao, G.M.M., C.V. Rao, P. Pushpangadan and A. Shirwaikar,2006Rubia cordifolia Linn.]]>103484490Hukkeri, V.I., B. Jaiprakash, M.S. Lavhale, R.V. Karadi and I.J. Kuppast,2002Alianthus excelsa Roxb. Leaf extracts on experimental liver damage in rats.]]>37105106Junnila, M., T. Rahko, A. Sukura and L.A. Lindberg,200037231238Kavithalakshmi, N., M. Narasimhan, K.R. Shanmugasundaram and E.R.B. Shanmugasundaram,20061057683Reitman, S. and S. Frankel,1957285663Kind, P.R.N. and E.J. King,19547132136King, J.,19651965Lin, S.C., T.C. Chung, T.H. Ueng, Y.H. Linn, S.H. Hsu, C.L. Chiang and Lin,2000Solanum alatam moech on acetaminophen-Induced hepatotoxicity in mice.]]>28105114Luly, P., O. Branahel and E. Tria,1972283447451Malloy, H.T. and K.A. Evelyn,1937119481490Meyer, S.A. and A.P. Kulkarni,20013rd Edn.pp: 487pp: 487Naidoo, V., H. Chikoto, L.C. Bekker and J.N. Eloff,2006Rhoicissus tridentata extracts may explain their antibabesial activity.]]>102198200Nkosi, C.Z., A.R. Opoku and S.E. Terblanche,2005Cucurbita pepo) protein isolate on the activity levels of certain plasma enzymes in CCl4-induced liver injury in low-protein fed rats.]]>19341345Oguntola, S.,20072007Opoku, A.R., I.M. Ndlovu, S.E. Terblanche and A.H. Hutchings, 2007In vivo hepatoprotective effects of Rhoicissus tridentata sub sp. cuneifolia, a traditional Zulu medicinal plant, against CCl4-induced acute liver injury in rats.]]>73372377Pandit, S., T.K. Sur, U. Jana, P.K. Debnath, S. Sen and D. Bhattacharyya,2004Adhatoda vasica leaves.]]>36312313Recknagel, R.O., E.A. Glende, Jr., J.A. Dolak and R.L. Waller,198943139154Reitman, S. and S. Frankel,1957285663Rosen, H.R. and E.B. Keefe,19981998pp: 812-820pp: 812-820Senthil Nathan, S., P.G. Chung and K. Murugan,2005Cnaphalocrocis medinalis. (Lepidoptera: Pyralidae).]]>33187195Shahani, S.,1999in vivo in rats.]]>36628631Singh, Y.N.,1992371345Szasz, G.,196915124136Upadhyay, R.K., M.B. Pandey, R.N. Jha and V.B. Pandey,2001Eclipta alba.]]>3213217Varley, H.,19674th Edn.pp: 161-162pp: 161-162Venukumar, M.R. and M.S. Latha,2002coscinium fenestratum in carbon tetra chloride treated rats.]]>46223228Wolf, P.L.,1999145990Wybenga, D.R., V.J. Pileggi, P.H. Dirstine and J. Di Giorgio,197016980984Gornall, A.G., C.J. Bardawill and M.M. David,1949177751766