Asian Journal of Biochemistry 1815-9923 1815-9931 Academic Journals Inc. 10.3923/ajb.2007.427.431 Chattopadhyay P. Sukla G. Gautam R. Singh L. Verma A. Verma N. Kumar S. Wahi A.K. 6 2007 2 6 The internucleosomal cleavage of genomic DNA is a biochemical hallmark of apoptosis. DNase endonuclease has been suggested to be one of the apoptotic endonuclease, but its biochemical characteristic has not been fully elucidated in ischemic and reperfusion (IR) injury. The present study suggests that DNase-I is involved in the apoptosis of IR injured rat liver The finding suggests a possible biological basis of endonuclease associated apoptotic effects of DNA in ischemic and reperfused hepatocytes.

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