Asian Journal of Animal and Veterinary Advances1683-99191996-3289Academic Journals Inc.10.3923/ajava.2022.164.168Alternanthera sessilis]]>RameshD.K. MruthyunjayaJ.H. KumarB. PrasannaKatagiManjunatha S.42022174Background and Objective: The current α-amylase and α-glucosidase inhibitors in clinical use such as acarbose, miglitol and voglibose are associated with undesirable side effects such as hypoglycemia, flatulence and diarrhoea due to the inhibitory effect of gastrointestinal digestion which limits their use in the treatment of diabetes when compared to the active principles of plant origin. This study explores the antidiabetic enhancing property of Alternanthera sessilis with cow’s urine as compared to aqueous extract. Materials and Methods: The aqueous and cow’s urine extract of Alternanthera sessilis was prepared by maceration and both extracts were subjected for in vitro α-amylase inhibitory activity. The obtained data were compared and analysed by MS office excel. Results: Cow urine has enhanced the time of hydrolysis of starch by α-amylase, which in turn exhibited an inhibitory effect on the α-amylase enzyme. Conclusion: From the research work it was revealed that cow’s urine extract shows promising α-amylase inhibitory activity compared to aqueous extract. The cow’s urine distillate as a solvent for the extraction and compare the α-amylase inhibitory activity of cow’s urine extract with aqueous extract and analyze the bio-enhancing effect on bio-active principles of aqueous extract.]]>Guariguata, L., D.R. Whiting, I. Hambleton, J. Beagley, U. Linnenkamp and J.E. Shaw,2014103137149Aryangat, A.V. and J. Gerich,20106145155Jain, S. and S. Saraf,201044856Yin, Z., W. Zhang, F. Feng, Y. Zhang and W. Kang,20143136174Gurav, N., S. Gurav, M. Wanjari, S. Prasad, S. Wayal and N. Rarokar,2021Kaamdev ghrita' in rat model.]]>12294301Sharma, P., T. Balichwal and K.B. Malav,20219593599Harshad, G., N. Amit, M. Nilesh, B. Sunanda and S. Amrut,2017816Rayilla, D. and P. Goverdhan,2017Alternanthera Sessilis in experimentally induced type 2 diabetes.]]>124447Hossain, A.I., M. Faisal, S. Rahman, R. Jahan and M. Rahmatullah,2014Alternanthera sessilis aerial parts.]]>2014Tukun, A.B., N. Shaheen, C.P. Banu, M. Mohiduzzaman, S. Islam and M. Begum,20147S568S573Mondal, H., S. Saha, K. Awang, H. Hossain and A. Ablat et al.,2014Alternanthera sessilis in mice.]]>2014Ashok, L., G.P. Sujatha and G. Hema,201021486490Soud, R.S.A., L.I. Hamdan and F.U. Afifi,2004722533Kashyap, V. and B. Dhanashree,202242517522Sharma, A., R. Nigam, S. Dixit, V. laxmi and S. Singh,2019517Randhawa, G.K. and R. Sharma,20154180186Singh, U.P., S. Maurya, A. Singh, G. Nath and M. Singh,20124515461557Manalo, R.A.M., E.C. Arollado and F.M. Heralde III,2020Alternanthera sessilis leaf fractions possess in vitro inhibitory activities in mammalian α-amylase and α-glucosidase.]]>47279286Chai, T.T., C.S. Khoo, C.S. Tee and F.C. Wong,2016Alternanthera sessilis: Comparative analyses of leaf and callus solvent fractions.]]>12253258