Asian Journal of Animal and Veterinary Advances1683-99191996-3289Academic Journals Inc.10.3923/ajava.2016.469.476OndaKen NodaChikako NakamuraKazue SatoReiichiro OchiaiHideharu AraiSachiko MadarameHiroo KawaiKazuhiro SunagaFujiko 82016118Background: This study investigated changes in the blood acid-base balance to determine the effects of Lactated Ringers Solution (LRS) administration in a steer with liver damage caused by carbon tetrachloride (CCl4) administration and in a cow with a fatty liver caused by a parturient negative energy balance. Materials and Methods: The LRS was administered to the CCl4 steer before CCl4 administration and 2, 7 and 11 days after CCl4 administration. The fatty liver cow and a group of control cows were administered LRS once. The initiation of LRS infusion was designated time-point 0. Venous blood samples were collected periodically from time-point 0-360 min thereafter and parameters related to the acid-base balance were measured. Results: On day 2, blood pH of the CCl4 steer before LRS administration was 7.26 but it gradually increased after the initiation of LRS administration, before ultimately recovering to within the normal reference range. The HCO3 levels decreased transiently just after the administration of LRS on day 7, then rapidly returned normal. Despite the fatty liver cow having severe fat infiltration, there were no substantial differences in parameters related to the blood acid-base balance between the fatty liver cow and the control cows, after LRS administration. Conclusion: Even in a steer suffering from liver damage caused by CCl4 administration, lactate was metabolised in the liver and worked as an alkaliser. Therefore, LRS may be a safe extracellular replacement solution when administered at the recommended flow rate and dose (20 mL kg1 h1 and 30 mL kg1, respectively) to dairy cows in clinics.]]>Roussel, A.J.,201430429439Smith, G.W. and J. Berchtold, 201430409427Lorenz, I. and A. Gentile,201430317331Hartsfield, S.M.,1981179914916Lorenz, I.,2009179197203Bartholomew, M.L., L.B. Willet, T.T.Y. Liu and P.D. Moorhead,198764201209Yonezawa, L.A., S.S. Kitamura, R.M.S. Mirandola, A.C. Antonelli and E.L. Ortolani,200552292297Suzuki, K., J. Okumura, I. Abe, S. Iwabuchi, K. Kanayama and R. Asano,200264335340Maughan, R.J.,1982122231240Folch, J., M. Lees and G.H.S. Stanley,1957226497509Constable, P.D.,201430295316Roussel, A.J.,19906111123Hartmann, A.F. and M.J.E. Senn,1932r-lactate. I. Response of normal human subjects to the intravenous injection of sodium r-lactate.]]>11327335Nakagawa, M., K. Suzuki, F. Takahashi, K. Kamikatano, M. Koiwa and K. Taguchi,200971807809Kasari, T.R. and J.M. Naylor,1985187392397Cohen, R.D. and R. Simpson,197543661673Goldstein, S.M. and L.D. MacLean,197215318321Arai, K., M. Kawamoto, O. Yoge, H. Shiraki, K. Mukaida, M. Horibe and M. Morio,198635793799, (In Japanese)Isosu, T., Y. Akama, C. Tase, M. Fujii and A. Okuaki,19924117071713, (In Japanese)Tanifuji, Y., M. Uede and Y. Syuto,19833213471352Schumer, W., S.M. Gerald and M.N. Lloyd,1969118200205Yoshino, K., N. Katoh, K. Takahashi and A.Yuasa,199253951956Oikawa, S. and G.R. Oetzel,20068929993005