Asian Journal of Animal and Veterinary Advances1683-99191996-3289Academic Journals Inc.10.3923/ajava.2012.149.157Mycoplasma bovis in Sheep Pneumonia]]>KumarAmit VermaAmit K. GangwarNeeraj K. RahalAnu 2201272M. bovis is a common respiratory pathogen for cattle but it may produce similar disease complex conditions. It can be transmitted through litter, tools and the hands and clothing of the owners and handlers in sheep and goats. In comparisons to other mycoplasmas M. bovis shows relatively high resistance under some environmental conditions. The occurrence in sheep is rare but it causes severe economic losses. The present study revealed an outbreak of pneumonia in sheep flock leading to high morbidity and mortality. To get an idea of etiological agent of outbreak the samples were collected from morbid animals and during the postmortem from dead animals. Nasal and tracheal swabs, blood, serum, faecal samples and tissues from multiple organs were collected and examined in laboratory. The M. bovis was the etiological agent isolated from nasal swabs and lungs of infected and dead animals, respectively. Histopathological findings also supported mycoplasmic lesions in dead animals. As the success of treatment of the respiratory diseases due to M. bovis depends on the right choice of the compound, its distribution in the tissues and last but not least the simultaneous antibacterial effect in secondary and mixed infections, the in vitro antimicrobial drug sensitivity was performed to select the drug of choice for treatment. The antibiogram of isolate revealed Tylosin and Enrofloxacin with remarkable zone of inhibition. Therefore, tylosin was recommended as drug for treatment and flock recovered with in the period of 15 days. There was no further mortality and all the infected sheep recovered from the signs of illness. This seems to be the first report of M. bovis outbreak in sheep in country.]]>Ajala, M.K., O.S. Lamidi and S.M. Otaru,20083138146Almalaik, A.H.A., A.E. Bashar and A.D. Abakar,20083390399Ayling, R.D., S.E. Baker, R.A.J. Nicholas, M.L. Peek and A.J. Simon,2000in vitro activity of danofloxacin, florfenicol, oxytetracycline, spectinomycin and tilmicosin against recent field isolates of Mycoplasma bovis.]]>146745747Ball, H.J., C. Reilly and D.G. Bryson,1995Mycoplasma bovis strains isolated in Northern Ireland.]]>48316318Bell, S.,2008300200207Bocklisch, H., V. Zepezauer, H. Pfutzner and S. Kreusel,1987Mycoplasma arginini.]]>41249257Bradbury, J.M.,19981998pp: 119-125pp: 119-125Brogden, K.A., H.D. Lehmkuhi and R.C. Cutlip,199829233254Carter, G.R., M.M. Chengappa and A.W. Roberts,19955th Edn.,Pages: 394Pages: 394Egwu, G.O., J.A. Ameh, M.M. Aliyu and F.D. Mohammed,2001398791Erno, H. and L. Stipkovits,197314436449Erno, H. and L. Stipkovits,197314450463Friis, N.F. and J. Szancer,199435389394Goodwin, K.A., R. Jackson, C. Brown, P.R. Davies, R.S. Morris and N.R. Perkins,200452175179Hannan, P.C.,200031373395Hannan, P.C., G.D. Windsor, A. de Jong, N. Schmeer and M. Stegemann,19974120372040Jones, G.E., A.C. Field, J.S. Gilmour, A.G. Rae, P.F. Nettleton and M. McLauchlan,1982110168173Kinde, H., B.M. Daft, R.L. Walker, B.R. Charlton and R. Petty,1993Mycoplasma bovis associated with decubital abscesses in Holstein calves.]]>5194197Bauer, A.W., W.M.M. Kirby, J.C. Sherris and M. Turck,196645493496Kirby, F.D. and R.A. Nicholas,1996Mycoplasma bovis from bullocks eyes.]]>138552552Al-Qudah, K.M., A.M. Al-Majali and M.M. Obaidat,20083269274Kumar, A.,2000Mycoplasma agalactiae.]]>2000Kumar, A., A.K. Verma and A. Rahal,2011Mycoplasma bovis, a multi disease producing pathogen: An overview.]]>6537546Lacasta, D., L.M. Ferrerb, J.J. Ramosb, J.M. Gonzaleza and M. De las Heras,2008802832Lauerman, L.H.,19941994pp: 50-56pp: 50-56Nagatomo, H., Y. Takegahara, T. Sonoda, A. Yamaguchi, R. Uemura, S. Hagiwara and M. Sueyoshi,200182223232NCCLS,20022nd Edn.,Nicholas, R.A.J. and R.D. Ayling,2003Mycoplasma bovis: Disease, diagnosis and control.]]>74105112Nicholas, R.A., S.E. Baker, R.D. Ayling and L. Stipkovits,20008115118Pfutzner, H. and K. Sachse,19961514771494Poumarat, F., M. Solsona and M. Boldini,1994Mycoplasma bovis.]]>40305321Quinn, P.J., B.K. Markey, M.E. Carter, W.J.C. Donnelly and F.C. Leonard,2002Pages: 648Pages: 648Rebhun, W.C., C. Guard and C.M. Richards,19951995pp: 79-80pp: 79-80Rodriguez, F., D.G. Bryson, H.J. Ball and F. Forster,1996Mycoplasma bovis pneumonia in calves.]]>115151162Rosengarten, R., A. Behrens, A. Stetefeld, M. Heller and M. Ahrens et al.,1994Mycoplasma bovis is generated by high-frequency variation of diverse membrane surface proteins.]]>6250665074Shayegh, J., S. Atashpaz and M.S. Hejazi,2008Pasteurella multocida.]]>3206213Stalheim, O.H.,197616910961097Stipkovits, L. M. Rady and R. Glavits,1993417388Taylor-Robinson, D. and C. Bebear,199740622630Ter Laak, E.A., J.H. Noordergraaf and M.H. Verschure,1993Mycoplasma bovis, Mycoplasma dispar and Ureaplasma diversum strains to antimicrobial agents in vitro.]]>37317321Ter Laak, E.A., G.H. Wentink and G.M. Zimmer,1992Mycoplasma bovis in the Netherlands.]]>14100104Thomas, A., I. Dizier, A. Trolin, J. Mainil and A. Linden,200226333339Thomas, A., C. Nicolas, I. Dizier, J. Mainil and A. Linden,2003Mycoplasma bovis in Belgium.]]>153428431Thompson, R.G.,1978pp: 412-413pp: 412-413Tibbo, M., M. Woldemeskel and A. Gopilo,200133355365Walz, P.H., T.P. Mullaney, J.A. Render, R.D. Walker, T. Mosser and J.C. Baker,1997Mycoplasma bovis.]]>9250254Woldemeskel, M., M. Tibbo and L.N. Potgieter,2002109486488