Asian Journal of Animal and Veterinary Advances1683-99191996-3289Academic Journals Inc.10.3923/ajava.2012.1290.1300WangC. XieP. LiuL.L. DongX.Y. LuJ.J. ZouX.T. 122012712Pharmacological level of zinc oxide is a common recommendation of swine
industries, but that could produce metal toxicity to plants and soil microorganisms.
The objective of this study was to evaluate the use of lower level of capsulated
zinc oxide as an alternative to pharmacological level of zinc oxide for weaned
piglets. In this study, 90 weaned piglets were randomly assigned into 3 groups
(each group with 3 replicates, 10 piglets per replicate) and were fed with the
basal diet supplemented with 0 (the control group), 3000 mg kg-1 zinc
from zinc oxide (the zinc oxide group) and 1500 mg kg-1 zinc from
capsulated zinc oxide (the capsulated zinc oxide group) for 7 days. Results
indicated that lower level of capsulated zinc oxide tended to increase the average
daily gain (p = 0.062), significantly decreased diarrhea ratio (p<0.01) and
significantly increased the serum concentrations of immunoglobulins and zinc
(p<0.01) compared to the control group. Serum concentration of insulin-like
factor-I (IGF-I), mRNA levels for IGF-I in liver, jejunum and mRNA level for
zonula occludens protein-1 (ZO-1) in jejunum were markedly improved by capsulated
zinc oxide. There was no difference between zinc oxide group and capsulated
zinc oxide group, except for the fecal zinc concentration. Lower level of capsulated
zinc oxide significantly decreased the fecal zinc concentration compared to
the zinc oxide group (p<0.01). These results showed that lower level of capsulated
zinc oxide exhibited beneficial effects on weaned piglets and could be an alternative
to pharmacological level of zinc oxide in weaned piglets.]]>Wegener, H.C.,20036439445Jondreville, C., P.S. Revy and J.Y. Dourmad,200384147156Carlson, M.S., G.M. Hill and J.E. Link,19997711991207Hill, G.M., D.C. Mahan, S.D. Carter, G.L. Cromwell and R.C. Ewan et al.,200179934941Li, X., J. Yin, D. Li, X. Chen, J. Zang and X. Zhou,200613617861791Li, B.T., A.G. Van Kessel, W.R. Caine, S.X. Huang and R.N. Kirkwood,200181511516Hahn, J.D. and D.H. Baker,19937130203024Owusu-Asiedu, A., C.M. Nyachoti and R.R. Marquardt,2003Escherichia coli (K88) challenge when fed diets containing spray-dried porcine plasma or pea protein isolate plus egg yolk antibody, zinc oxide, fumaric acid, or antibiotic.]]>8117901798Smith, J.W., M.D. Tokach, R.D. Goodband, J.L. Nelssen and B.T. Richert,19977518611866Li, P., Y.L. Yin, D. Li, S.W. Kim and G. Wu,200798237252NRC.,199810th Edn.,Xu, Z.R., C.H. Hu, M.S. Xia, X.A. Zhan and M.Q. Wang,20038210301036Kim, J.C., C.F. Hansen, J.R. Pluske and B.P. Mullan,20102010Fang, J., F.Y. Yan, X.F. Kong, Z. Ruan and Z.Q. Liu et al.,2009Acanthopanax senticosus extract enhances gut health in weanling piglets.]]>123268275Pluske, J.R., D.J. Hampson and I.H. Williams,199751215236Frydendahl, K.,2002Escherichia coli associated with postweaning diarrhoea and edema disease in pigs and a comparison of diagnostic approaches.]]>85169182Armstrong, T.A., D.R. Cook, M.M. Ward, C.M. Williams and J.W. Spears,20048212341240Wedekind, K.J., A.J. Lewis, M.A. Giesemann and P.S. Miller,19947226812689Ou, D., D. Li, Y. Cao, X. Li, J. Yin, S. Qiao and G. Wu,200718820826Wang, Y.Z., T.Z. Shan, Z.R. Xua, J. Feng and Z.Q. Wang,2007135263272Erika, K. and B. Knudsena,200160291299Shelton, N.W., M.D. Tokach, J.L. Nelssen, R.D. Goodband, S.S. Dritz, J.M. DeRouchey and G.M. Hill,20118924402451Alexander, A.N. and H.V. Carey,1999277G619G25Bruewer, M., A. Luegering, T. Kucharzik, C.A. Parkos, J.L. Madara, A.M. Hopkins and A. Nusrat,200317161646172Fanning, A.S., B.J. Jameson, L.A. Jesaitis and J.M. Anderson,19982732974529753Finamore, A., M. Massimi, C.C. Devirgiliis and E. Mengheri,200813816641670Fukawa, K., N. Nishimura, O. Irino and K. Nitta,1982918321837Furuse, M., T. Hirase, M. Itoh, A. Nagafuchi, S. Yonemura, S. Tsukita and S. Tsukita,199612317771788Gendelman, M. and Z. Roth,20128619Hollis, G.R., S.D. Carter, T.R. Cline, T.D. Crenshaw and G.L. Cromwell et al.,20058321232129Huang, S.X., M. McFall, A.C. Cegielski and R.N. Kirkwood,1999Escherichia coli septicemia in weaned pigs.]]>7109111Huo, J.Y., T. Wang, R.J. Xu, S. Macdonald, G. Liu and F.X. Shi,200689265273Kucharzik, T., S.V. Walsh, J. Chen, C.A. Parkos and A. Nusrat,200115920012009Kuscher, W.G., A. D'Alessandro, H. Wong and P.D. Blanc,199775711L'Herroux, L., S. Le Roux, P. Appriou and J. Martinez,199797119130Mylonas, P.G., P.T. Matsouka, E.V. Papandoniou, C. Vagianos, F. Kalfarentzos and T.K. Alexandrides,2000160115122Osek, J.,1999Escherichia coli strains isolated from diarrheic and healthy piglets after weaning.]]>68209217Rubio, L.A., R. Ruiz, M.J. Peinado and A. Echavarri,20108835903597Tietz, N.W., C.A. Burtis, P. Duncan, K. Ervin, C.J. Petitclerc, A.D. Rinker, D. Shuey and E.R. Zygowicz,198329751761Wang, Y., J.W. Tang, W.Q. Ma, J. Feng and J. Feng,2009133325334Wittig, W., H. Klie, P. Gallien, S. Lehmann, M. Timm and H. Tschape,1995Escherichia coli isolated from weaned pigs.]]>28395104Xu, S.D., J. Lee and M. Miyake,201220147158Yin, J., X. Li, D. Li, T. Yue and Q. Fang et al.,200820783790Yu, Z.P., G.W. Le and Y.H. Shi,200532273278Zhang, B. and Y. Guo,2009102687693Case, C.L. and M.S. Carlson,20028019171924Odle, J., T. Zijlstra and S.M. Donovan,19967425092522