Asian Journal of Animal and Veterinary Advances1683-99191996-3289Academic Journals Inc.10.3923/ajava.2012.128.138KhajehpourLotfollah MollahoseiniSana KesmatiMahnaz Abdol-Rahman Rasekh 2201272The effects of glucocorticoids on brain functions such as modulation of learning and memory are well documented. This study was conducted to examine the involvement of acetylcholine muscarinic receptors (mAChRs) of the baso-lateral amygdala (BLA) in the impairment effect of dexamethasone on memory retrieval. Adult male Wistar rats (220-250 g) were bilaterally cannulated in the BLA by stereotaxic surgery. The animal were trained and tested in the step-through apparatus, that consisted of two compartments which were connected via a small door, after one week. The rats were trained by induction of electric shock (1 mA, 3 sec) and then thay were tested for memory retrieval 24 h later (without receive shock). The time of latency (Step-through latencies) for entering the place of receiving the sock, the dark compartment of the instrument and the time spent by rats in this chamber (Time spent in dark chamber) were recorded for evaluation of the passive avoidance memory retrieval. Administration of the dexamethasone (2 mg kg-1, s.c.) before testing impaired memory retrieval. This effect of dexamethasone was reversed by pre-test administration of different doses of pilocarpine (1, 2 μg/rat, intra-BLA), a muscarinic receptor agonist. Whiles, Pre-test co-administration of low doses of scopolamine (0.3 and 0.5 μg/rat, intra-BLA), a muscarinic receptor antagonist, with the ineffective dose of the dexamethasone (0.5 mg kg-1, s.c.) impaired memory retrieval. However, the same doses of pilocarpine and scopolamine without dexamethasone did not affect memory processes. Our findings indicate that mechanisms of the mAChRs of the BLA may be mediates the impairment effect of dexamethasone on memory retrieval.]]>Boccia, M.M., M.G. Blake, G.B. Acosta and C.M. Baratti,200334597100Boccia, M.M., G.M. Blake, C.M. Baratti and J.L. McGaugh,2009919397Bodnar, R.J.,20103123252359Carballo-Marquez, A., A.Vale-Martinez, G. Guillazo-Blanch and M. Marti-Nicolovius,20099198101Dalmaz, C., I.B. Introini-Collison and J.L. McGaugh,199358167174De Quervain, D.J.F., A. Aerni, G. Schelling and B. Roozendaal,200930358370Douma, B.R.K., K. Jansen, S.M. Korte, B. Buwalda, E.A. Van der Zee and P.G.M. Luiten,19992684144Duvarci, S. and D. Pare,20072744824491Hajisoltani, R., A. Rashidy-Pour, A.A. Vafaei, B. Ghaderdoost, A.R. Bandegi and F. Motamedi,20112197581Helm, K.A., J.S. Han and M. Gallagher,2002115765774Introini-Collison, I.B., C. Dalmaz and J.L. McGaugh,1996655764Khajehpour, L., A. Rezayof and M.R. Zarrindast,2008584343351Koyano, S., Y. Saito, S. Ozawa, A. Miyajima and J.I. Sawada,20051316323Lee, J.H., J.Y. Lee, S.B. Yoo and J.W. Jahng,20084184189McGaugh, J.L.,200427128McGaugh, J.L., K.C. McIntyre and A.E. Power,200278539552McGaugh, J.L. and B. Roozendaal,20082008pp: 521-553pp: 521-553McReynolds, J.R., K. Donowho, A. Abdi, J.L. McGaugh, B. Roozendaal and C.K. McIntyre,201093312321Mikics, E., M.R. Kruk and J. Haller,200429618635Moazedi, A.A.I., M. Belaran, A. Hemmaty and A. Rasekh,200843439Ali, M.A., K.S. Maryam and P.G. Ali,201010648652Moazedi, A.A., Z. Ghotbeddin and G.H. Parham,20071027042708Moazedi, A.A., Z. Valizadeh and G.A. Parham,20088416420Pakdel, R. and A. Rashidy-Pour,200685300306Paxinos, G. and C. Watson,20076th Edn.,Pare, D.,200370409420Power, A.E. and J.L. McGaugh,2002134307315Power, A.E., B. Roozendaal and J.L. McGaugh,20001234813487Power, A.E., A.Vazdarjanova and J.L. McGaugh,200380178193Rahim, F., B. Keikhaei, A. Sarkaki and A.H. Doulah, 201051323Rashidy-Pour, A., H. Sadeghi, A.A. Taherain, A.A. Vafaei and Y. Fathollahi,2004154193198Rashidy-Pour, A., A.A. Vafaei, A.A. Taherian, H. Miladi-Gorji, H. Sadeghi, Y. Fathollahi and A.R. Bandegi,20092037680Rassouli, Y., A. Rezayof and M.R. Zarrindast,201086887893Rezayof, A., L. Khajehpour and M.R. Zarrindast,2009160255263Rezayof, A., P. Habibi and M.R. Zarrindast,2011175118126Roozendaal, B.,200025213238Roozendaal, B., S. Okuda, D.J.F. de Quervain and J.L. McGaugh,2006138901910Roozendaal, B., G.P. Marquez and J.L. McGaugh,199611010741083Sajadi, A.A., S.A. Samaei and A. Rashidy-Pour,2006173158162Sajadi, A.A., S.A. Samaei and A.R. Pour,200752347354Takahashi, L.K. and C.S. Goh,19988311451153Tehranipour, M. and M. Kafaee,2010106770Tehranipour, M. and M.R. Khakzad,2008810271032Tizabi, Y., V.H. Gilad and G.M. Gilad,1989105177182Vafaei, A.A., A. Rashidy-Pour and A.A. Taherian,200869241241Venturella, R., D. Lessa, T. Luft, B. Roozendaal, G. Schwartsmann and R. Roesler,200526821825Zarrindast, M.R., J. Meshkani, A. Rezayof, R. Beigzadeh and P. Rostami,2010168505513Zarrindast, M.R., S. Ahmadi, A. Haeri-Rohani, A. Rezayof, M.R. Jafari and M. Jafari-Sabet,200410064958