Asian Journal of Animal and Veterinary Advances1683-99191996-3289Academic Journals Inc.10.3923/ajava.2012.1183.1190LiuLing-Bin LiDi-Yan ZhaoXiao-Ling LiuYi-Ping WangYan ZhuQing 112012711Prolactin Receptor (PRLR), as an important regulatory gene about growth and
differentiation, might be a candidate gene for reproductive traits. The purpose
in the present study was to analyze the association of Single Nucleotide Polymorphisms
(SNPs) of exon 6 in prolactin receptor gene with egg production traits in Erlang
mountainous chickens, a native breed from Poultry farm of Sichuan Agricultural
University which consisted of two pure lines SD02 and SD03. Polymerase Chain
Reaction-single-strand Conformation Polymorphism (PCR-SSCP) and DNA sequencing
methods were used. Results showed that One SNP (G1836C) which had not yet been
reported was found and two alleles (G, C) and two genotypes (GG, CC) were also
detected. It observed significant differences in allelic and genotypic frequencies
among all the chicken populations. Genotype frequencies in all chicken for GG
and CC were 56.22 and 43.78%, respectively. Associations of polymorphisms of
the PRLR gene with egg production traits were analyzed by using a GLM procedure.
The CC genotype had extremely significant effect on Age at First Egg (AFE) (p<0.01)
and the AFE of CC genotype had 3.75 days earlier than GG genotype. There was
no significant association of G1836C with BWFE; body weight at first egg, WFE;
weight at first egg, EN; egg number during 300 days after hatch, BWTA; body
weight at 300 days of age and WTE; egg weight at 300 days of age. Therefore,
the study showed that the PRLR gene may either a major gene that influences
age at first egg of chicken or a molecular marker in close linkage with such
a gene.]]>Alamer, M.,2011611531169Boutin, J.M., M. Edery, M. Shirota, C. Jolicoeur and L. Lesueur et al.,1989314551461Cao, G.Q., B.G. Li, J.H. Liu and W.P. Yang,20043253255Chen, H.Q., H.Q. Wei, J. Qin and H. Chen,2011610691075Chen, H.Q., J. Qin, Y.J. Zhu, Z.T. Pan and Y.N. Xie et al.,20127802811Chen, J., H. Liu, Y. Cai, G. Wang, H. Liu and J. Li,201239475483Clarke, D.L. and D.I. Linzer,1993133224232Cui, J.X., H.L. Du, Y. Liang, X.M. Deng, N. Li and X.Q. Zhang,2006852631Drogemuller, C., H. Hamann and O. Distl,20017925652570Dunn, I.C.,1998392324Elferink, M.G., A.A.A. Vallee, A.P. Jungerius, R.P.M.A. Crooijmans and M.A.M. Groenen,2008PRLR and SPEF2 genes at the late feathering locus in chicken.]]>2008Hong, K.Y., F. Wang, D.B. Yu and W.X. Du,2007161114Horseman, N.D., W. Zhao, E. Montecino-Rodriguez, M. Tanaka and K. Nakashima et al.,19971669266935Jenkins, Z., H. Henry, J. Sise and G. Montgomery,200031280280Jiang, R.S., G.Y. Xu, X.Q. Zhang and N. Yang,200584839845Jie, H, H.D. Yin, Y.P. Liu, Q. Zhu, Y. Zhang and X.L. Zhao,2010289092Kelly, P.A., N. Binart, B. Lucas, B. Bouchard and G. Vincent,200122140145Jun, L.W., F. Yi, S.Y. Gang, F.G. Xin and T.K. Chuan et al.,20105402409Putnova, L., A. Knoll, J. Dvorak and S. Cepica, 2002HpaII PCR-RFLP within the porcine prolactin receptor PRLR gene and study of its effect on litter size and number of teats.]]>119 5763Scott, P., M.K. Kessler and L.A. Schuler,1992894758Shirota, M., D. Banville, S. Ali, C. Jolicoeur and J.M. Boutin et al.,1990411361143Tanaka, M., K. Maeda, T. Okubo and K. Nakashima,1992188490496Van Rens, B.T.T.M. and T. van der Lende,200257883893Van Rens, B.T.T.M., G.J. Evans and T. van der Lende,200359915926Vincent, A., L. Wang, C.K. Tuggle, K. Tuggle and M.F. Rothschild,1998292729Qiong, W., F. Chao, L. Wu-Jun, F. Yi and Y. Shi-Gang,20116627635Wells, J.A. and A.M. de Vos,199665609634Xiao, L.H., S.Y. Chen, X.L. Zhao, Q. Zhu and Y.P. Liu,201148162167Xing, G., Q. Zhao, J. Mao, T. Liu and G. Wang,20119010501057Zhang, G.X., M.X. Chu, J.Y. Wang, L. Fang and S.C. Ye,200729329336Han, B., H.L. Zhang, L. Zeng, B. Yang, R. Abula, X.L. Xu and Y. Chen,20112-Adrenergic Receptor Gene on two Cattle Breeds in China]]>6715722Kimchi-Sarfaty, C., J.M. Oh, I.W. Kim, Z.E. Sauna, A.M. Calcagno, S.V. Ambudkar and M.M. Gottesman,2007MDR1 gene changes substrate specificity.]]>315525528