Asian Journal of Animal and Veterinary Advances1683-99191996-3289Academic Journals Inc.10.3923/ajava.2012.1166.1174Centaurea bruguierana ssp. belangerana]]>KhanaviMahnaz TaheriMarzieh RajabiAfsaneh Fallah-BonekohalSaeed BaeeriMaryam MohammadiradAzadeh AminGholamreza AbdollahiMohammad 112012711The aqueous, dichloromethane, ethyl acetate and methanol extracts of dried
aerial fruiting parts of Centaurea bruguierana ssp. belangerana
were investigated for hypoglycemic mechanism in diabetic rats. Diabetes was
induced by intravenous administration of streptozotocin-alloxan. The methanol
and ethyl acetate extracts were administered in a single effective dose of 200
mg kg-1 and dichloromethane and aqueous extracts were administered
in a single effective dose of 400 mg kg-1. Blood glucose was determined
every 1 h until 3 h post administration of the extracts. In the second experiment,
the liver was surgically removed 3 h post treatment of diabetic rats with various
extracts, homogenized and used for measurement of key enzymes of glycogenolysis
(glycogen phosphorylase, GP) and gluconeogenesis (phosphoenolpyruvate carboxykinase,
PEPCK). Treatment by dichloromethane, ethyl acetate, methanol and aqueous extracts
and the glibenclamide, reduced blood glucose to 41.7, 55.0, 45.7, 29.5 and 34.5%,
respectively. The aqueous extract showed the best effect in reduction of hepatic
PEPCK activity (84.0%) and increased hepatic GP activity (134.5%), while glibenclamide
showed 62.5 and 133.0% activity, respectively. None of the extracts affected
blood insulin. Presence of sugar in dried aqueous extract could suppress the
hypoglycemic effect during the first hour of the experiment. After 1 h, the
hepatic mechanism overwhelmed and thus lowering effect in blood glucose appeared.
The conclusion is that C. bruguierana ssp. belangerana is able
to lower blood glucose via stimulation of hepatic glycogenolysis and inhibition
of gluconeogenesis.]]>Akkal, S., F. Benayache, K. Medjroubi, F. Tillequin and E. Seguin,2003Centaureafurfuracea (Asteraceae).]]>31641643Ali, B.H., A.K. Bashir and R.A. Rasheed,1997Centaurea damascene in alloxan-induced diabetes in rats.]]>25493494Black, H.E., I.Y. Rosenblum and C.C. Capen,198098295309Celik, S., S. Rosselli, A.M. Maggio, R.A. Raccuglia and I. Uysal et al.,2006Centaur eaptosimopappa.]]>34349352Chucla, M.T., A. Lamela, I. gato and I. Cadavidi,198854107109Flamini, G., M. Pardinim and I. Morelli,2001Centaurea bracteata.]]>5812291233Flamini, G., M. Pardini, I. Morelli, K. Ertugrul, H. Dural, Y. Bagci and M. Kargioglu,2002Centaurea Pseudo Scabiosa ssp. pseudoscabiosa from Turkey.]]>61433437Harraz, F.M., F.F. Kassem and N.S. El-Shaer,1994Centaurea bruguierana.]]>8219222Hasani-Ranjbar, S., B. Larijani and M. Abdollahi,20084, 3285292Hasani-Ranjbar, S., B. Larijani and M. Abdollahi,20098210Hasani-Ranjbar, S., B. Larijani and M. Abdollahi,2011612711275Hasani-Ranjbar, S., N. Nayebi, B. Larijani and M. Abdollahi,20091530733085Hosseini, A. and M. Abdollahi,201286061Hoseini, S., H. Esmaily, A. Mohammadirad and M. Abdollahi,20062280285Khanavi, M., A. Rajabi, M. Behzad, A. Hadjiakhoondi, H. Vatandoost and M.R. Abaee,2011Centaurea bruguiera ssp. Belangerana against Anopheles stephensi Larvae.]]>10829833Khanavi, M., R. Ahmadi, A. Rajabi, S.J. Arfaee and A. Hassanzadeh et al.,2011Centaurea bruguiera ssp. belangerana on indomethacin-induced peptic ulcer in rats.]]>66343349Marco, J.A., J.F. Sanz-Cervera, A. Yuste, F. Sancenon and M. Carda,2005Centaurea aspera.]]>6616441650Masso, J.L.,1980Centaurea aspera L. (Compositae).]]>38217230Mohammadirad, A., H.R. Khorram-Khorshid, F. Gharibdoost and M. Abdollahi,2011TM) as a multiherbal drug with promising benefits in animal and human studies: A comprehensive review of biochemical and cellular evidences.]]>611851192Momtaz, S. and M. Abdollahi,2010Satureja species; From antioxidant, antimicrobial, antidiabetes and anti-hyperlipidemic to reproductive stimulation.]]>6346353Mostafalou, S. and M. Abdollahi,20128139140Rahimi, R., S. Nikfar, B. Larijani and M. Abdollahi,200559365373Robles, M., N. Wang, R. Kim and B.H. Choi,1997479097Rustaiyan, A., A. Niknejad and Y. Aynehchi,1982Centaurea brugueriana.]]>44185186Saadat, M., S. Pournourmohammadi, M. Donyavi, R. Khorasani, G. Amin, A.N. Salehnia and M. Abdollahi,2004Satureja khuzestanica Jamzad essential oil.]]>7327331Serrano-Martin, X., G. Payares and A. Mendoza-Leon,2006+ ATP channels, shows antileishmanial activity in experimental Murine Cutaneous Leishmaniasis.]]>5042144216Shoeb, M., S. Celik, M. Jaspars, Y. Kumarasamy and S. M. MacManus et al.,2005Centaurea schischkinii.]]>6190019006Shoeb, M., S.M. MacManus, M. Jaspars, J. Trevidadu, L. Nahar, P.K. Thoo-Lin and S.D. Sarker,2006Centaurea Montana (Asteraceae) and its in vitro cytotoxic activity against the CaCo2 colon cancer cells.]]>621117211177Yesilada, E., I. Gurbuz, E. Bedir, I. Tatli and I.A. Khan,2004Centaurea solstitialis L. ssp. solstitialis through bioassay-guided fractionation procedures in rats.]]>95213219WHO,20112011Villar, A. and M. Paya, 1985Centaure aseridis L. var. maritime, Lge.]]>19410Rechinger, K.H.,1980Vol. 139b.pp: 385-387pp: 385-387Kajbaf, F., M. Mojtahedzadeh and M. Abdollahi,2007497106