Asian Journal of Animal and Veterinary Advances1683-99191996-3289Academic Journals Inc.10.3923/ajava.2012.1148.1156Lactobacillus casei in Combination with Bifidobacterium bifidum or Saccharomyces boulardii in Recovery of Inflammatory Markers of Colitis in Rat]]>Ghasemi-NiriSeyedeh Farnaz SolkiSara DidariTina MozaffariShilan BaeeriMaryam RezvanfarMohammad Amin MohammadiradAzadeh JamalifarHossein AbdollahiMohammad 112012711Alteration of intestinal microflora has an important role in Inflammatory Bowel
Disease (IBD) and probiotics by balancing microflora and modulating inflammatory
cytokines seem effective in management of IBD. In the present study, two combinations
of probiotics Lactobacillus casei (L. casei) plus Bifidobacterium
bifidum (B. bifidum) or plus Saccharomyces boulardii (S.
boulardii) were tested for their potential to prevent or treat experimental
colitis in rats. Nine groups of animals including sham (normal group), control
(vehicle-treated), dexamethasone as standard, treatment groups (oral administration
of L. casei and mixture of (L. casei-B. bifidum and L. casei-S.
boulardii after induction of colitis) and prevention groups (oral administrations
of L. casei and mixture of (L. casei-B. bifidum and L. casei-S.
boulardii before induction of colitis) were used. Tumor necrosis factor-α
(TNF-α), myeloperoxidase (MPO) and lipid peroxidation (LPO) were determined
in all groups. In treatment groups, histological scores and TNF-α, MPO
and LPO levels attenuated significantly but colonic lesions in the prevention
groups did not recover. The results revealed that, combination of L. casei-B.
bifidum and L. casei-S. boulardii alleviated inflammatory parameters in
colitis but these combinations were ineffective to prevent colitis. In addition,
we found that mixture of probiotics is significantly more effective than L.
casei group in improving barrier function of epithelium in experimental
colitis model.]]>Abdolghaffari, A.H., A. Baghaei, F. Moayer, H. Esmaily and M. Baeeri et al.,201029287295Buts, J.P. and P. Bernasconi,2005Saccharomyces boulardii: Basic science and clinical applications in gastroenterology.]]>34515532Castagliuolo, I., J.T. LaMont, S.T. Nikulasson and C. Pothoulakis,1996Saccharomyces boulardii protease inhibits Clostridium difficile toxin A effects in the rat ileum.]]>6452255232Chawla, A., Y. Barak, L. Nagy, D. Liao, P. Tontonoz and R.M. Evans,200174852Czerucka, D. and P. Rampal,2002Saccharomyces boulardii on diarrheal pathogens.]]>4733739Elahi, B., S. Nikfar, S. Derakhshani, M. Vafaie and M. Abdollahi,20085312781284Fajas, L., D. Auboeuf, E. Raspe, K. Schoonjans and A.M. Lefebvre et al.,19972721877918789Ghasemi-Niri, S.F., A.H. Abdolghaffari, S. Fallah-Benakohal, M. Hosseinpour-Feizi and P. Mahdaviani et al.,2011Lactobacillus casei in murine colitis.]]>62341346Goossens, D., D. Jonkers, E. Stobberingh, A. van den Bogaard, M. Russel and R. Stockbrugger,20032391523Imaoka, A., T. Shima, K. Kato, S. Mizuno and T. Uehara et al.,2008Bifidobacterium: Enhancement of IL-10 production in peripheral blood mononuclear cell from ulcerative colitis patient and inhibiton of IL-8 secretion HT-29 cells.]]>1425112516Kelly, D., J.I. Campbell, T.P. King, G. Grant and E.A. Jansson et al.,20045104112Lee, S.K.., Y.W. Kim, S.G. Chi, Y.S. Joo and H.J. Kim,200954255263Nikfar, S., M. Darvish-Damavandi and M. Abdollahi,20106826835Nikfar, S., R. Rahimi, F. Rahimi, S. Derakhshani and M. Abdollahi, 20085117751780Rahimi, R., S. Nikfar, A. Rezaie and M. Abdollahi,20084185190Rahimi, R., S. Nikfar, F. Rahimi, B. Elahi, S. Derakhshani, M. Vafaie and M. Abdollahi,20085325242531Reddy, K.P., J.E. Markowitz, E.D. Ruchelli, R.N. Baldassano and K.A. Brown,200752365372Rezaie, A., R.D. Parker and M. Abdollahi,20075220152021Rosen, E.D. and B.M. Spiegelman,20012763773137734Salari, P., S. Nikfar and M. Abdollahi,201211314Tien, M.T., S.E. Girardin, B. Regnault, L. le Bourhis and M.A. Dillies et al.,2006Lactobacillus casei on Shigella-infected human intestinal epithelial cells.]]>17612281237Ghazanfari, G., B. Minaie, N. Yasa, L.A. Nakhai and A. Mohammadirad et al.,2006Satureja khuzestanica jamzad essential oil on the mouse model of inflammatory bowel diseases.]]>16365372