Asian Journal of Animal Sciences1819-1878xxxx-xxxxxAsian Network for Scientific Information10.3923/ajas.2016.224.234AleenaJoy PragnaPrathap ArchanaP.R. SejianVeerasamy BagathMadiajagan KrishnanGovindan ManimaranA. BeenaV. KurienE.K. VarmaGirish BhattaRaghavendra 4-52016104-5The animals possess various inherent mechanisms to cope up with the changing environmental conditions. It has been observed that the ability of the animals to adjust with these climatic extremes is related to their level of adaptation and this is inversely correlated with their production potential. In depth understanding of metabolic response of livestock adaptation might pave way for developing more viable adaptive measures to cope up livestock production system to climate change. Hence, this review is an attempt to cover the significance of metabolic response to animal adaptation during heat stress. In animals, less feed intake helps to reduce the internal heat production by minimizing the metabolic processes to adapt the heat stressed condition. Thyroid glands and thyroid hormones are mainly known to have a very important role in the thermoregulation and homeostasis of energy and protein metabolism. Further, the histological sections of the thyroid gland of livestock subjected to heat stress indicates pathological changes of less thyroglobulin in the thyroid cells reflecting a significant decrease in thyroid activity. Changes in the concentration of thyroid hormones in the blood reflect the metabolic and nutrient status of the body. Thyroid hormones play a critical role in thermogenesis and therefore are an important reflection of adaptation to heat stress in livestock species. The roles of metabolic regulators are crucial in assessing the physiological response to heat stress through various enzymes governing the metabolic reactions in blood. The decreased level of non-estrified fatty acid (NEFA) during heat stress condition in livestock is attributed to enhance the glucose burning as a presumable strategy to reduce metabolic heat production in the animal body. In addition, alteration in the levels of both aspartate aminotranspharase (AST) and alanine aminotranspharase (ALT) are correlated to adaptive potential of livestock to environmental challenges. Based on this review, it was concluded that metabolic response is one of the primary means by which the animals tries to cope up with heat stress challenges. The animal reduces their metabolic activities in an effort to reduce the metabolic heat production to cope up with outside environment heat stress condition.]]>Sejian, V., V.P. Maurya and S.M.K. Naqvi,201256243252Sejian, V., V.P. Maurya, K. Kumar and S.M.K. Naqvi,20122012Silanikove, N. and N. Koluman,20151232734Gaughan, J. and A.J.C. Smith,20152015pp: 51-60pp: 51-60Khazanehei, H., S. Li, E. Khafipour and J.C. Plaizier,201595445453Maurya, V.P., V. Sejian, M. Gupta, S.S. Dangi, A. Kushwaha, G. Singh and M. Sarkar,20152015pp: 123-140pp: 123-140Nguyen, T.T.T., P.J. Bowman, M. Haile-Mariam, J.E. Pryce and B.J. Hayes,20169928492862De Guia, R.M., A.J. Rose and S. Herzig,201419117128Bernabucci, U., N. Lacetera, L.H. Baumgard, R.P. Rhoads, B. Ronchi and A. Nardone,2010411671183Sejian, V., V.P. Maurya and S.M.K. Naqvi,201054653661Wheeler, T. and J. von Braun,2013341508513Vermeulen, S.J., B.M. Campbell and J.S.I. Ingram,201237195222Sejian, V., R.S. Srivastava and V.P. Varshney,201087503504Sejian, V., M. Bagath, S. Parthipan, B.G. Manjunathareddy and S. Selvaraju et al.,20155755769Chen, Y., R. Arsenault, S. Napper and P. Griebel,2015512681295Mirkena, T., G. Duguma, A. Haile, M. Tibbo, A.M. Okeyo, M. Wurzinger and J. Solkner,2010132112Dias e Silva, T.P., J.N. da Costa Torreao, C.A.T. Marques, M.J. de Araujo, L.R. Bezerra, D.K. Dhanasekaran and V. Sejian,2016593946Silanikove, N.,200067118Kolli, V., R.C. Upadhyay and D. Singh,201496102110Kadzere, C.T., M.R. Murphy, N. Silanikove and E. Maltz,2002775991Nardone, A., B. Ronchi, N. Lacetera, M.S. Ranieri and U. Bernabucci,20101305769Bagath, M., V. Sejian, S.S. Archana, G.B. Manjunathareddy and S. Parthipan et al.,2016137279Das, R., L. Sailo, N. Verma, P. Bharti, J. Saikia, Imtiwati and R. Kumar,20169260268Baumgard, L.H. and R.P. Rhoads Jr.,20131311337Shilja, S., V. Sejian, M. Bagath, A. Mech and C.G. David et al.,20166013111323Sejian, V. and R.S. Srivastava,201044101107Sejian, V. and R.S. Srivastava,201066339349Brown-Brandl, T.M., R.A. Eigenberg, J.A. Nienaber and G.L. Hahn,200590451462Staples, C.R. and W.W. Thatcher,20112011pp: 561-566pp: 561-566Finch, V.A.,198662531542Farooq, U., H.A. Samad, F. Shehzad and A. Qayyum,201083843Hansen, P.J.,200482-83349360Marai, I.F.M., A.A. El-Darawany, A. Fadiel and M.A.M. Abdel-Hafez,20077112Fouad, A.M., W. Chen, D. Ruan, S. Wang, W.G. Xia and C.T. Zheng,2016158195Rhoads, M.L., R.P. Rhoads, M.J. VanBaale, R.J. Collier and S.R. Sanders et al.,20099219861997Maurya, V.P., V. Sejian and S.M.K. Naqvi,201383370373Yasothai, R.,2014316851690Avendano-Reyes, L., F.D. Alvarez-Valenzuela, A. Correa-Calderon, A. Algandar-Sandoval and E. Rodriguez-Gonzalez et al.,20101324852Indu, S., V. Sejian and S.M.K. Naqvi,20142014Baumgard, L.H., J.B. Wheelock, G. Shwartz, M.O. Brien and M.J. van Baale et al.,20062006pp: 817Sejian, V., V.P. Maurya and S.M.K. Naqvi,20104217631770Naqvi, S.M.K., V. Sejian and S.A. Karim,201345143148Sejian, V., V.P. Maurya, K. Kumar and S.M.K. Naqvi,201245107116Lamp, O., M. Derno, W. Otten, M. Mielenz, G. Nurnberg and B. Kuhla,20152015Pereira, A.M.F., F. Baccari Junior, E.A.L. Titto and J.A.A. Almeida,200852199208Hooda, O.K. and G. Singh,201027122127Verma, D.N., S.N. Lal, S.P. Singh and O. Parkash,2000152237244Marai, I.F.M., A.A.M. Habeeb and A.E. Gad,2002787190Kaliber, M., N. Koluman and N. Silanikove,2016108288Hamzaoui, S., A.A.K. Salama, E. Albanell, X. Such and G. Caja,20139663556365Sejian, V., S. Bahadur and S.M.K. Naqvi,201464189205Sejian, V., A.K. Singh, A. Sahoo and S.M.K. Naqvi,2014987283Indu, S., V. Sejian and S.M.K. Naqvi,201455766776Mahjoubi, E., M.H. Yazdi, N. Aghaziarati, G.R. Noori, O. Afsarian and L.H. Baumgard,20159316321640Sejian, V., V.P. Maurya and S.M.K. Naqvi,201195252258Indu, S., V. Sejian, D. Kumar, A. Pareek and S.M.K. Naqvi,20154714871495Pearce, S.C., N.K. Gabler, J.W. Ross, J. Escobar, J.F. Patience, R.P. Rhoads and L.H. Baumgard,20139121082118Mashaly, M.M., G.L. Hendricks, M.A. Kalama, A.E. Gehad, A.O. Abbas and P.H. Patterson,200483889894Ondruska, L., J. Rafay, A.B. Okab, M.A. Ayoub and A.A. Al-Haidary et al.,20114180186Huszenicza, G., M. Kulcsar and P. Rudas,200247199210Abdul Niyas, P.A., K. Chaidanya, S. Shaji, V. Sejian and R. Bhatta et al.,20152015Todini, L., 200719971008Djokovic, R., H. Samanc, J. Bojkovski and N. Fratric,2010433440Melesse, A., S. Maak, R. Schmidt and G. von Lengerken,20113 levels in commercial layer hens.]]>2107116Saber, A.P.R., M.T. Jalali, D. Mohjeri, A.A. Akhoole, H.Z.N. Teymourluei, M. Nouri and S. Garachorlo,200942833Fliers, E., A. Kalsbeek and A. Boelen,2014171197208Omidi, A., M. Kheirie and H. Sarir,20155103106Doubek, J., S. Slosarkova, P. Fleischer, G. Mala and M. Skrivanek,200348403411Rasooli, A., M. Nouri, G.H. Khadjeh and A. Rasekh,2004513831391Hussin, A.M. and M.M. Al-Taay,2009Bubalus bubalis) with referring to the seasonal changes.]]>82638Beyzai, A.R. and M. Adibmoradi,20111014961501Sejian, V., S. Indu and S.M.K. Naqvi,20138311551160Pereira, A.M.F., F. Baccari Junior, E.A.L. Titto and J.A.A. Almeida,200852199208Kahl, S., T.H. Elsasser, R.P. Rhoads, R.J. Collier and L.H. Baumgard,2015524350Horowitz, M.,200126357363Kumar, B., A.K. Ishwar, P.K. Choudhary and T. Akhatar,2015811371142Marai, I.F.M. and A.A.M. Haeeb,201012789109Habeeb, A.A.M., A.J. Aboulnaga and T.H. Kamal,20012001pp: 97108Nessim, M.G.,20042004Mader, T.L., J.B. Gaughan, L.J. Johnson and G.L. Hahn,201054629635Abdel-Fattah, M.S.,201430543555Helal, A., A.L.S. Hashem, M.S. Abdel-Fattah and M.H. El-Shaer,201076069Hooda, O.K. and R.C. Upadhyay,201410214227Sivakumar, A.V.N., G. Singh and V.P. Varshney,20102314621468Al-Samawi, K.A., M.J. Al-Hassan and A.A. Swelum,201448344349Wheelock, J.B., R.P. Rhoads, M.J. VanBaale, S.R. Sanders and L.H. Baumgard,201093644655Baumgard, L.H. and R.P. Rhoads,20129018551865Shehab-El-Deen, M.A.M.M., J.L.M.R. Leroy, M.S. Fadel, S.Y.A. Saleh, D. Maes and A. van Soom,2010117189200Upah, N., S. Pearce, N.K. Gabler and L.H. Baumgard, 20112011Alberghina, D., G. Piccione, S. Casella, M. Panzera, M. Morgante and M. Gianesella,201356354359Wenz, J.R., L.K. Fox, F.J. Muller, M. Rinaldi, R. Zeng and D.D. Bannerman,20109324582470Gupta, A.R., S. Dey, D. Swarup, M Saini, A. Saxena and A. Dan,2013Tamarindus indica L. on biochemical parameters of serum and urine in cattle from fluoride endemic area.]]>83487496Nazifi, S., M. Saeb, E. Rowghani and K. Kaveh,200312135139Banerjee, D., R.C. Upadhyay, U.B. Chaudhary, R. Kumar, S. Singh, A.T.K. Das and S. De,201546221236Alameen, A.O. and A.M. Abdelatif,20121210651074Sharma, A.K. and N. Kataria,201181293295