Asian Journal of Animal Sciences1819-1878xxxx-xxxxxAsian Network for Scientific Information10.3923/ajas.2013.1.13Lippia nodiflora
L. on Ethanol Induced Liver Injury in Rats]]>SudhaA. SumathiK. ManikandaselviS. PrabhuN.M. SrinivasanP. 1201371The present study was undertaken to evaluate the hepato-protective effect of
crude flavonoid fraction of aerial parts of Lippia nodiflora in ethanol
induced oxidative stress in liver using experimental animal models. Ethanol-fed
(5 g kg-1 day-1) male rats were treated by crude flavonoid
fraction (25, 50 mg kg-1) for 21 days. The liver damage was indicated
by the significant increase in serum AST, ALT, ALP, LDH, total bilirubin, urea
and decrease in total protein and triglyceride (TG). Lipid peroxidation markers
like Thiobarbituric Acid Reactive Substances (TBARS) and antioxidant enzymes
namely superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH),
Glutathione Reductase (GR) and Glutathione-S-transferase (GST) activities were
also measured. The crude flavonoid fraction showed significant (p<0.05) protective
effect by decreasing the elevated liver marker enzymes, total bilirubin, lipid
peroxidation marker and ameliorated the diminished serum total protein as well
as antioxidant levels in a dose dependent manner. The protective effect of the
crude flavonoid fraction was observed at both concentrations and was compared
to that of the standard used. Hence, our results highlights the ability of crude
flavonoid fraction of Lippia nodiflora to ameliorate oxidative damage
in the liver and the observed effects are associated with its antioxidant activities.]]>Achliya, G.S., S.G. Wadodkar and A.K. Dorle,200490229232Adaramoye, O.A., I. Awogbindin and J.O. Okusaga,2009Garcinia kola seeds, on ethanol-induced oxidative stress in liver of adult Wistar rats.]]>12584590Aebi, H.,1984In vitro.]]>1984pp: 121-126pp: 121-126Ahmed, F., M.S.T. Selim, A.K. Das and M.S.K. Choudhuri,2004Lippia nodiflora Linn.]]>59329330Akerboom, T.P.M. and H. Sies,198177373382Albano, E.,200665278290Balamurugan, R. and S. Ignacimuthu,2011Lippia nodiflora L. in streptozotocin induced diabetic rats.]]>1S30S36Balasubramaniyan, V., J.K. Sailaja and N. Nalini,200347211216Bandyopadhyay, U., D. Das and R.K. Banerjee,199977658666Buege, J.A. and S.D. Aust,19781978pp: 302-310pp: 302-310Bhakuni, D.S., M.L. Dhar, M.M. Dhar, B.N. Dhawan and B.N. Mehrotra,19697250262Bousquet, B.F., R. Julien, R. Bon and C. Dreux,197129415415Carlberg, I. and B. Mannervik,197525054755480Caro, A.A. and A.I. 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