An Antisalmonellal Agent from the Leaves of Glossocalyx brevipes Benth (Monimiaceae)

, Donatien Gatsing; , James A. Mbah; , Ibrahim H. Garba; , Pierre Tane; , Pierre Djemgou; , Bridget F. Nji-Nkah

Research Article

**An Antisalmonellal Agent from the Leaves of Glossocalyx brevipes Benth (Monimiaceae)**

Donatien Gatsing, James A. Mbah, Ibrahim H. Garba, Pierre Tane, Pierre Djemgou and Bridget F. Nji-Nkah

ABSTRACT

Three homogentisic acid derivatives, namely methyl 2-(1`β-geranyl-5`β-hydroxy-2`-oxocyclohex-3`-enyl)acetate (1), 2-(1`β-geranyl-5`β-hydroxy-2`-oxocyclohex-3`-enyl)acetic acid (2), methyl 2-(1`β-geranyl-5`β-hydroxy-4`β-methoxy-2`-oxocyclohexyl)acetate (3), isolated from the leaves of Glossocalyx brevipes, were screened for antisalmonellal activity using both agar diffusion and broth dilution techniques. Only compound 2 showed significant antimicrobial activity against Salmonella typhi (26 mm), Salmonella paratyphi A (23 mm) and Salmonella paratyphi B (22 mm). The MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration) values were 10 and 80 μg mL^-1, respectively, against all the three bacteria strains used. These data support the use of Glossocalyx brevipes in anti-typhoid preparations.

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Donatien Gatsing, James A. Mbah, Ibrahim H. Garba, Pierre Tane, Pierre Djemgou and Bridget F. Nji-Nkah, 2006. An Antisalmonellal Agent from the Leaves of Glossocalyx brevipes Benth (Monimiaceae). Pakistan Journal of Biological Sciences, 9: 84-87.

DOI: 10.3923/pjbs.2006.84.87

URL: https://scialert.net/abstract/?doi=pjbs.2006.84.87

REFERENCES

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Pakistan Journal of Biological Sciences

Research Article

**An Antisalmonellal Agent from the Leaves of Glossocalyx brevipes Benth (Monimiaceae)**

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