The effect of graded doses of aqueous leaf extract of Parquetina nigrescens on erythrocyte indices and serum electrolytes was studied for two weeks on rats following acute blood loss. Red blood cell count, haemoglobin concentration, haematocrit, reticulocyte population and erythrocyte osmofragility were used as erythrocyte indices. The plasma electrolytes concentrations of sodium, potassium, calcium and bicarbonate were analysed. Parquetina nigrescens significantly (p < 0.05) increased the erythrocyte indices which were initially reduced by bleeding except for erythrocyte osmofragility which instead decreased significantly (p < 0.05). Parquetina nigrescens had no effect on serum electrolyte except for sodium ion concentration which increased significantly (p < 0.05). The improved erythrocyte indices and reduced erythrocyte osmofragility are indications of erythropoietic potential of Parquetina nigrescens.
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G.A. Agbor and A.A. Odetola, 2005. Effect of Parquetina nigrescens on Erythrocyte Indices and Serum Electrolytes of Rats Following Acute Blood Loss. Pakistan Journal of Biological Sciences, 8: 527-531.
- Datte, J.Y., A. Ziegler and J.P. Tillement, 1999. Sympathomimetic effects of Parquetina nigresens (periplocaceae) extract in isolated portal vein smooth muscle. Gen. Pharmacol., 32: 551-556.
- Agbor, G.A., J.E. Oben, B.O. Brahim and J.Y. Ngogang, 2004. Toxicity study of Hibiscus cannabinus. J. Cameroon Acad. Sci., 4: 27-32.
- Di Carlo, G., N. Mascolo, A.A. Izzo and F. Capasso, 1994. Effect of quercetin on the gastrointestinal tract in rats and mice. Phytother. Res., 8: 42-45.
- Saror, D.I., T.W.S. van Venn and J.B. Adeyanju, 1979. The haemogram of dogs with intestinal parasites in Zaria, Nigeria. J. Small Anim. Practice, 20: 243-247.