Submit Manuscript

International Journal of Pharmacology

Year: 2006 | Volume: 2 | Issue: 1 | Page No.: 45-49
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
Research Article

Aqueous Extracts of Andographis paniculata Improve Lipid Profiles of Rats Fed with High Cholesterol Diet

A. Zuraini, M.R. Ros Aziah, A.K. Arifah, M.R. Sulaiman and M.N. Somchit

ABSTRACT

The aim of present study was to investigate the potential roles of aqueous extracts of A. paniculate in lowering the plasama lipid parameter which is responsible for hyperlipidemia and its damaging consequences and also to determine the kidney and liver functions of rats. Plasma Total Cholesterol (TC), Low Density Lipoproteins (LDL) cholesterol and Triglycerides (TG) had progressively increased in cholesterol-fed rats up to 4 weeks of cholesterol-feeding. Both 100 and 200 mg kg 1 concentrations of A. paniculata extracts had kept TC, LDL and TG values within the normal range even after 4 weeks of feeding. No significant enhancement was found in the amount of High Density Lipoproteins (HDL) cholesterol and the kidney and liver enzymes of the rats, i.e. Blood Urea Nitrogen (BUN), total creatinine and Lactate Dehydrogenase (LDH) and Aspartate Amino Transferase (AST) and Alanine Aminotransferase (ALT), respectively indicating normal kidney and liver functions. From the current study, it can be concluded that 100 and 200  mg kg 1 aqueous extract of A. paniculata appeared to possess great potentials as anti-hyperlipidemic agent in rats.
PDF References Citation

Search

REFERENCES

  1. Gupta, S., M.A. Choudhry, J.N.S. Yadava, V. Srivastava and J.S. Tandon, 1990. Antidiarrheal activity of diterpenes of Andrographis paniculata Kalmegh against Escherichia coli enterotoxin in in vivo models. Int. J. Crude Drug Res., 4: 273-283.
  2. Sharma, A., L. Krishan and S.S. Handa, S.S. 1992. Standardization of the Indian crude drug Kalmegh by high pressure liquid chromatographic determination of andrographolide. Phytochem. Anal., 3: 129-131.
  3. Weiming, C. and L. Xiaotion, 1982. Deoxyandrographolide 19β-D-glucoside from the leaves of A. paniculata. Planta Med., 15: 245-246.
  4. Assy, N., K. Kaita, D. Mymin, C. Levy, B. Rosser and G. Minuk, 2000. Fatty infiltration of liver in hyperlipidemic patients. Dig. Dis. Sci., 45: 1929-1934.
    CrossRefPubMed
  5. Quyyumi, A.A., 1998. Endothelial function in health and disease: New insights into the genesis of cardiovascular disease. Am. J. Med., 105: 32S-39S.
    Direct Link
  6. Zhang, X.F. and B.K. Tan, 2000. Antihyperglycaemic and anti-oxidant properties of Andrographis paniculata in normal and diabetic rats. Clin. Exp. Pharmacol. Physiol., 27: 358-363.
    Direct Link
  7. Zhang, C.Y. and B.K.H. Tan, 1996. Hypotensive activity of aqueous extract of Andrographis paniculata in rats. Clin. Exp. Pharmacol. Physiol., 23: 675-678.
    CrossRefDirect Link
  8. Madav, H.C., T. Tripathi and S.K. Mishra, 1995. Analgesic, antipyretic and antiulcerogenic effects of andrographolide. Indian J. Pharm. Sci., 57: 121-125.
    Direct Link
  9. Wang, D.W. and H.Y. Zhao, 1993. Experimental studies on prevention of atherosclerotic arterial stenosis and restenosis after angioplasty with Andrographis paniculata nees and fish oil. J. Tongji Med. Univ., 13: 193-198.
    CrossRefDirect Link
  10. Huang, L.Y., 1987. The effects of andrographolides on experimental blood deficiency of cardiac muscle. Chinese Herbal Med., 18: 26-28.
  11. Zhao, H. and W. Fang, 1990. Protective effects of Andrographis paniculata Nees on post-infarction myocardium in experimental dogs. J. Huazhong Univ. Sci. Technol. Med. Sci., 10: 212-217.
    CrossRefDirect Link
  12. Wang, H.W., H.Y. Zhao and S.Q. Xiang, 1997. [Effects of Andrographis paniculata component on nitric oxide, endothelin and lipid peroxidation in experimental atherosclerotic rabbits]. Chin. J. Integr. Tradit. Western Med., 17: 547-549, (In Chinese).
    PubMedDirect Link
  13. Yokozawa, T., A. Ishida, E.J. Cho and T. Nakagawa, 2003. The effects of Coptidis Rhizoma extract on a hypercholesterolemic animal model. Phytomedicine, 10: 17-22.
    CrossRefDirect Link
  14. Moghadasian, M.H., 2002. Experimental atherosclerosis: A historical overview. Life Sci., 70: 855-865.
    Direct Link
  15. Madav, S., S.K. Tandan, J. Lal and H.C. Tripathi, 1996. Anti-inflammatory activity of andrographolide. Fitotherapia, 67: 452-458.
    Direct Link

Search

Related Articles

Leave a Comment

Your email address will not be published. Required fields are marked *