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International Journal of Pharmacology

Year: 2005 | Volume: 1 | Issue: 4 | Page No.: 376-382
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ABSTRACT

Benzodiazepines (BZDs) are the most commonly prescribed hypnotic-anexiolytic-sedative drugs in the world. Their effectiveness and safe usage have made them extremely popular among patients. To date more than 30 different brands of BZDs have been introduced to drug market, which vary enormously in side effects, potency and indications. Thus, due to global consumption and diversity of BZDs, lack of a information indicating the BZDs` side effects sorted by induced signs and symptoms, this study would ease the consultation and follow-up of the patients who have undergone BZD treatment. The review first gives a brief introduction about side effects encountered by BZDs and then classifies the signs and symptoms based on the organ involved and mentions which BZDs are responsible for them. The organs and functions which are influenced are classified under: cardiovascular system, CNS, cognitive function, mood changes, endocrine/metabolic, gastrointestinal tract, blood and bone marrow, liver, eyes, respiratory system, skin, genitourinary tract, musculoskeletal system, ears and miscellaneous. Each of these items is also sub-grouped into several categories.
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Hournaz Karimpour, , Sarvenaz Karimpour, Mohammad Jafar Zamani, Shekoufeh Nikfar, Ali Rezaie, Naghmeh Hajarolasvadi, Shahin Shadnia and Mohammad Abdollahi, 2005. Toxic Reactions to Chronic Use of Benzodiazepines: An Overview. International Journal of Pharmacology, 1: 376-382.

DOI: 10.3923/ijp.2005.376.382

URL: https://scialert.net/abstract/?doi=ijp.2005.376.382

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REFERENCES

  1. Fauci, A.S., 1998. Harrison's Principles of Internal Medicine. 14th Edn., Toronto, McGraw-Hill, New York.
  2. Gold, M.S., N.S. Miller, K. Stennie and C. Populla-Vardi, 1995. Epidemiology of benzodiazepine use and dependence. Psychiatr. Ann., 25: 146-148.
    Direct Link
  3. Janicak, P.G., 2001. Principles and Practice of Psychopharmacotherapy. 3rd Edn., Lippincott Williams and Wilkins, Philadelphia,.
  4. Wonsiewicz, M.J., 2001. Adams and Victor's Principles of Neurology. 7th Edn., McGraw-Hill, Philadelphia,.
  5. Roache, J.D. and R.A. Meisch, 1995. Finding from self-administration research on the addiction potential of benzodiazepines. Psychiatr. Ann., 25: 153-157.
  6. Longo, L. and B. Johnson, 2000. Addiction: Part 1. Benzodiazepines side effects, abuse risk and alternatives. Am. Family Physician, 61: 2121-2128.
  7. Moller, H., 1999. Effectiveness and safety of benzodiazepines. J. Clin. Pharmacol., 19: 2-11.
  8. Greenblatt, D.J., 1991. Benzodiazepine hypnotics: Sorting the pharmacokinetic facts. J. Clin. Psychiatry, 52: 4-10.
  9. Abdollahi, M., M. Rahbar-Haghighat and K. Soltaninejad, 2002. Prevention by flumazenil of benzodiazepines-suppressed of rat submandibular gland function. Indian J. Pharmacol., 34: 164-171.
  10. Abdollahi, M. and M. Radfar, 2003. A review of drug-induced oral reactions. J. Contemp. Dental Pract., 4: 10-31.
  11. Weinberg, D.S. and S.L. Kadish, 1996. The diagnosis and management of gastroesophageal reflux disease. Med. Clin. North Am., 80: 411-429.
  12. Luton, E.F. and R.N. Finchum, 1965. Photosensitivity reaction to chlordiazepoxide. Arch. Dermatol., 91: 362-363.
  13. Blair, H.M., 1974. Fixed drug eruption from chlordiazepoxide: Report of a case. Arch. Dermatol., 109: 914-914.
  14. Jafferany, M. and T.S. Haroon, 1988. Fixed drug eruption with lormetazepam (Noctamid). Dermatologica, 177: 386-386.
  15. Archer, C.B. and J.S.C. English, 1988. Extensive fixed drug eruption induced by temazepam. Clin. Exp. Dermatol., 13: 336-338.
  16. Nishioka, K., I. Katayama, M. Masuzawa, H. Yokozeki and S. Nishiyama, 1989. Drug-induced chronic pigmented purpura. J. Dermatol., 16: 220-222.
    Direct Link
  17. Almeyda, J., 1971. Drug reactions X III. Cutaneous reactions to imipramine and chlordiazepoxide. Br. J. Dermatol., 84: 298-299.
  18. Fernandez-Real, J.M., W. Ricart-Engel and M. Camafort-Babkowski, 1994. Hyponatremia and benzodiazepines result in rhabdomyolysis. Ann. Pharmacother., 28: 1200-1201.
    PubMedDirect Link
  19. Strohmaier, A. and M. Friedrich, 1991. Nicht-traumatisches Compartmentsyndrom beider Unterschenkel infolge einer akuten Rhabdomyolyse. Fortschr. Rontgenstr., 15: 277-279.
  20. Abdollahi, M., H. Karimpour and S. Khalaj, 2003. Drug-induced skin reactions. J. Pharm. Pract. Res., 33: 12-15.
  21. Wakakura, M., T. Subouchi and J. Inouye, 2004. Etizolam and benzodiazepine induced blepharospasm. J. Neurol. Neurosurg. Psychiatry, 75: 506-507.
    Direct Link
  22. Epstein, D.L., 1997. Chandler and Grants Glaucoma. 4th Edn., Williams and Wilkins, Baltimore.
  23. Davies, D.M., R.E. Ferner and H. DeGlanville, 1998. Davies's Textbook of Adverse Drug Reactions. 5th Edn., Chapman and Hall, London.
  24. Janicak, P.G., J.M. Davis, S.H. Preskorn and Jr. F.J. Ayd, 2001. Treatment with Antianxiety and Sedative Hypnotic Agents. Principles and Practice of Psychotherapy. 3rd Edn., Williams and Wilkins, Lippincott, Philadelphia, pp: 471-512.

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