Effect of Lactational Exposure to an Aqueous Extract of Hibiscus sabdariffa on Body Mass Index at Onset of Puberty in Female Sprague - Dawley Rats
Abstract:
The present study aimed to investigate whether or not maternal consumption of aqueous extract of Hibiscus sabdariffa (HS) during lactation has any effect on the body weight and body mass index at onset of puberty in the female offspring. Eighteen in-bred virgin female Sprague-Dawley rats aged between 10-12 weeks and weighing 125±5.5g (mean±SEM) with two consecutive regular 4-day estrus cycle were used for this study. On the day of delivery, the dams and their pups were randomly assigned to one of three groups of 6 rats/group. One group had tap water (control), another had 0.6g-HSextract/100ml in their drinking water while the third group had 1.8g-HSextract/100ml in their drinking throughout lactation. Results showed that maternal consumption of aqueous extract of HS during lactation at the doses tested, delayed onset of puberty and elevated body weight and body mass index at onset of puberty in female offspring.
How to cite this article
E.E. Iyare and O.A. Adegoke, 2011. Effect of Lactational Exposure to an Aqueous Extract of Hibiscus sabdariffa on Body Mass Index at Onset of Puberty in Female Sprague - Dawley Rats. Pakistan Journal of Nutrition, 10: 360-364.
REFERENCES
Banks, W.A., A.J. Kastin, W. Huang, J.B. Jaspan and L.M. Maness, 1996. Leptin enters the brain by a saturable system independent of insulin. Peptides, 17: 305-311.
CrossRef
Blum, W.F., P. Englaro, S. Hanitsch, A. Juul and N.T. Hertel et al., 1997. Plasma leptin levels in healthy children and adolescents: Dependence on body mass index, body fat mass, gender, pubertal stage and testosterone. J. Clin. Endocrin. Metab., 82: 2904-29010.
CrossRef Direct Link
Butte, N.F., J.M. Hopkinson and M.A. Nicolson, 1997. Leptin in human reproduction: Serum leptin levels in pregnant and lactating women. J. Clin. Endocrinol. Metab., 82: 585-589.
Direct Link
Butzow, T.L., J.M. Moilanen and M. Lehtovirta, 1999. Serum and follicular fluid leptin during in vitro fertilization: Relationship among leptin increase, body fat mass and reduced ovarian response. J. Clin. Endocrinol. Metab., 84: 3135-3139.
Direct Link
Chehab, F.F., M.E. Lim and R. Lu, 1996. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat. Genet., 12: 318-320.
CrossRef PubMed Direct Link
Considine, R.V., M.K. Sinha, M.L. Heiman, A. Kriaucinas and T.W. Stephens et al., 1996. Serum immunoreactive leptin concentrations in normal weight and obese humans. N. Engl. J. Med., 334: 292-295.
Direct Link
Engelbregt, M.J.T., M.E.C.A.M. Houdijk, C. Popp-Snijders and H.A.D.V. de Waal, 2000. The effects of intrauterine growth retardation and postnatal undernutrition on onset of puberty in male and female rats. Pediatr. Res., 48: 803-807.
Direct Link
Engelbregt, M.J.T., M.M. van Weissenbruch, C. Popp-Snijders, P. Lips and H.A.D.V. de Waal, 2001. Body mass index, body composition and leptin at onset of puberty in male and female rats after intrauterine growth retardation and after early postnatal food restriction. Pediatr. Res., 50: 474-478.
Direct Link
Frederich, R.C., A. Hamann, S. Anderson, B. Lollman, B.B. Lowell and J.S. Flier, 1995. Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action. Nat. Med., 1: 1311-1314.
CrossRef
Frisch, R.E., 1980. Pubertal adipose tissue: Is it necessary for normal sexual maturation? Evidence from the rat and human female. Fed. Proc., 39: 2395-2400.
Direct Link
Frisch, R.E., D.M. Hegsted and K. Yoshinaga, 1977. Carcass components at first estrus of rats on high-fat and low-fat diets: Body water, protein and fat. Proc. Natl. Acad. Sci. USA., 74: 379-383.
Direct Link
Glass, A.R., D.C. Herbert and J. Anderson, 1986. Fertility onset, spermatogenesis and pubertal development in male rats: Effects of graded underfeeding. Pediatr. Res., 20: 1161-1167.
Direct Link
Guzman, C., R. Cabrera, M. Cardenas, F. Larrea, P.W. Nathanielsz and E. Zambrano, 2006. Protein restriction during fetal and neonatal development in the rat alters reproductive function and accelerates reproductive aging in female progeny. J. Physiol., 572: 97-108.
Direct Link
Hales, C.N. and D.J. Barker, 1992. Type 2 (non-insulin-dependent) diabetes mellitus: The thrifty phenotype hypothesis. Diabetologia, 35: 595-601.
CrossRef
Hoet, J.J. and M.A. Hanson, 1999. Intrauterine nutrition: Its importance during critical periods for cardiovascular and endocrine development. J. Physiol., 514: 617-627.
CrossRef
Hoggard, N., L. Hunter, J.S. Duncan, L.M. Williams, P. Trayhurn and J.G. Mercer, 1997. Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta. Proc. Natl. Acad. Sci., 94: 11073-11078.
CrossRef
Horlick, M.B., M. Rosebaum, M. Nicolson, L.S. Levine and B. Fedun et al., 2000. Effect of puberty on relationship between circulating leptin and body composition. J. Clin. Endocrinol. Metab., 85: 2509-2518.
CrossRef
Iyare, E.E. and A.O. Adegoke, 2008. Postnatal weight gain and onset of puberty in rats exposed to aqueous extract of Hibiscus sabdariffa in utero. Pak. J. Nutr., 7: 98-101.
CrossRef Direct Link
Kennedy, G.C. and J. Mitra, 1963. Body weight and food intake as initiating factors for puberty in the rat. J. Physiol. (Lond)., 166: 408-418.
PubMed
Maffei, M.J., J. Halaas, E. Ravussin, R.E. Pratley and G.M. Lee et al., 1995. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat. Med., 1: 1155-1161.
CrossRef Direct Link
Mojiminiyi, F.B.O., B.J. Adegunloye, Y.A. Egbeniyi and R.U. Okolo, 2000. An investigation of the diuretic effect of an aqueous extract of the petal of Hibiscus sabdariffa. J. Med. Sci., 2: 77-80.
Ojokoh, A.O., 2006. Roselle (Hibiscus sabdariffa) calyx diet and histopathological changes in liver of albino rats. Pak. J. Nutr., 5: 110-113.
CrossRef Direct Link
Orisakwe, O.E., D.C. Hussaini, D.N. Akunyili, A.A. Njan, D.D. Akumka and O.O. Udemezue, 2004. Subchronic administration of Nigerian species of Hibiscus Sabdarffa calyx in rats did not produce cardiotoxicity. Eur. Bull. Drug Res., 12: 1-5.
Direct Link
Twisk, J.W., H.C. Kemper, W. van Mechelen, G.B. Post van and F.J. Lenthe, 1998. Body fatness: Longitudinal relationship of body mass index and the sum of skinfolds with other risk factors for coronary heart disease. Int. J. obes Relat. Metab. Disord., 22: 915-922.
PubMed
Wade, G.N. and J.E. Schneider, 1992. Metabolic fuels and reproduction in female mammals. Neurosci. Biobehav. Rev., 16: 235-272.
Direct Link
Wade, G.N., J.E. Schneider and H.Y. Li, 1996. Control of fertility by metabolic cues. Am. J. Physiol., 270: E1-E19.
Direct Link
Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold and J.M. Friedman, 1994. Positional cloning of the mouse obese gene and its human homologue. Nature, 372: 425-432.
CrossRef Direct Link
© Science Alert. All Rights Reserved