Abstract: Most of thalassemic patients have with deficiency of anti-oxidants and increase of oxidative stress and few studies have been performed on deficiency of vitamins A, E, C in these patients. In this research we intend to study the antioxidants intake and its relationship with anemia indices in children with thalassemia. This study is a retrospective study which was performed on the children with thalassemia in Sabzevar and Mashhad cities. The sampling method was target-based. In this study, 85 patients with thalassemia were examined. After taking written consent and filling the demographic questionnaire, their height and weight were measured through the common standard methods. Then, two questionnaires of two day meal reminder and meal frequency were completed for them (in order to determine the rate and pattern of receiving antioxidant in the present and the past) and 5cc of blood was taken from each of them so that the blood indices could be measured. The data gathered using statistical SPSS software and applying the correlation coefficient, linear regression, t test, Analysis of Variance (ANOVA) the relationships were analyzed. In this study 85 patients were studied, 48(56.5%) of whom were females and 37(43.5%) of them were males. The average age of them is 16.97±7.02 years-old and mean BMI of them was 19.03±3.71 kg/m2. The mean antioxidants received in these patients are vitamin A 883.35±1140.58 mcg, vitamin E 4.08±3.89 mg, vitamin C 204.40±238.71 mg and selenium 160±120 mcg, respectively. Among these antioxidants only vitamin C has a direct and significant correlation with hematocrit in the patients (p<0.05). In this study, between receiving vitamin A, MCV and MCH levels in the patients with thalassemia an inverse and significant relationship was observed.