Comparative Efficacy of Two Medicinal Plant Extracts and an Antibiotic on Wound Healing
Abstract:
The present investigation was carried out to study the comparative efficacy
of two medicinal plant extracts and an antibiotic on wound healing. This was
conducted on 18 female goats at BAU Veterinary Clinic. Infiltration anesthesia
was performed with 2% lignocaine hydrochloride (Jasocaine®, Reneta Pharmaceuticals
Ltd.) at the site of operation on lumber region. Four experimental skin wounds,
two in either side of the midline plane at the lumbar region were made, each
was of 2.5 cm length and 0.5 cm depth. The experimental animals were studied
under 6 Groups. A series of 50 and 30% extracts of border plant (Aerva sanguinolenta),
thankuni plant (Centella asiatica), antibiotic (Pronapen®) and saline
were used in this experiment and these were applied twice daily to each wound.
All extracts seemed to be effective for rapid healing. A 50% extracts of border
plant showed the best result where healing time was 14 days whereas in antibiotic
it took 16 days. In contrast more time (20 days) was required for control group.
Clinical feature revealed exudation, scab formation, redness and other routine
changes. Redness was more prominent in control and antibiotic treated groups
compare to other groups on day 3 of wounding. Thus both border and thankuni
plant extracts are very much effective for wound healing and can be applied
instead of antibiotic.
How to cite this article
M. M. Alam, S. A. Islam, Y. Mohammed, N. S. Juyena and M. A. Hashim, 2005. Comparative Efficacy of Two Medicinal Plant Extracts and an Antibiotic on Wound Healing. Pakistan Journal of Biological Sciences, 8: 740-743.
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