HOME JOURNALS CONTACT

Pakistan Journal of Biological Sciences

Year: 2005 | Volume: 8 | Issue: 4 | Page No.: 586-588
DOI: 10.3923/pjbs.2005.586.588
Acute Toxicity and Phytochemical Studies of Cassia siamea Extract in Rats
I. M. Wiam, T. W. Jacks and Y. A. Zongoma

Abstract: The toxicological effects of the ethanol extract of Cassia siamea were investigated in rats. Acute toxicity study was conducted following intraperitoneal administration of graded doses of the plant extract. LD50 of Cassia siamea extract was found to be 9600 mg kg-1 body weight. Mortality occurred in rats treated with high doses of 4000, 5000, 6000, 7000, 8000 and 16000 mg kg-1 and appears to be dose dependent. Phytochemical analysis of ethanol extract of Cassia siamea leaf indicated that it contained alkaloids, glycosides, anthraquinones, steroids, tannins and saponins.

Fulltext PDF

How to cite this article
I. M. Wiam, T. W. Jacks and Y. A. Zongoma, 2005. Acute Toxicity and Phytochemical Studies of Cassia siamea Extract in Rats. Pakistan Journal of Biological Sciences, 8: 586-588.

Keywords: Rats, cassia siamea and acute toxicity

REFERENCES
  • Etkin, N.L. and P.J. Ross 1983. Malaria, Medicine and Meals: Plant Use Among the Hausa and its Impact on Disease. In: The Anthropology of Medicine: From Culture to Method, Romanucci-Ross, L., D.E. Moerman and L.R. Tancredi (Eds.). Praeger, New York and Washington, pp: 231-259

  • Hussian, H.S.N., 1991. Plant in Kano ethnomedicme: Screening for antimicrobial activity and alkaloids. J. Pharmacol., 29: 51-56.

  • Bannerman, R.H.O., J. Burton, C. Wen-Chieh and W.C. Chaen, 1983. Traditional Medicine and Health Care Coverage. World Health Organization, Geneva

  • Evans, W.C. and G.E. Trease, 1989. Trease and Evans' Pharmacognosy. 13th Edn., Baillière Tindall, London, ISBN: 9780702013577, Pages: 832
    Direct Link    

  • Clarke, E.G.C., 1975. Isolation and Identification of Drugs. Vol. 2, Pharmaceutical Press, London, pp: 905

  • Odebiyi, O.O. and E.A. Sofowora, 1978. Phytochemical screening of Nigerian medicinal plants II. Lioydia, 41: 234-246.
    PubMed    

  • Aliyu, Y.O. and N. Nwude, 1982. Veterinary Pharmacology and Toxicology Experiments. 1st Edn., Baraka Press and Publishers, Zaria, pp: 43-45

  • Mead, R. and R.N. Curnow, 1982. A Simple Experiment in Statistical Methods in Agriculture and Experimental Biology. Champman Hall, London, pp: 33-46

  • Dennis, V.P., 1984. Mammalian Metabolism of Xenobiotic Chemicals. In: Toxicology and Newborn, Kacew, S. and M.J. Reasor (Eds.). Elsevie, New York, pp: 1-31

  • Clark, E.G.C. and M.L. Clark, 1977. Veterinary Toxicology. 2nd Edn., Bailliere Tindall, New York, pp: 10

    • © Science Alert. All Rights Reserved