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Pakistan Journal of Biological Sciences

Year: 2005 | Volume: 8 | Issue: 12 | Page No.: 1798-1801
DOI: 10.3923/pjbs.2005.1798.1801
Significance of Prostate Specific Antigen for the Diagnosis and Treatment of Prostate Cancer
Tanveer Khanum, Ajaz Rasool, M. Hanif, Samreen Idrees, Shahid Kamal, Aliya Hayat and Rafia Azmat

Abstract: A prospective study has been planned to ascertain the most common form of cancer in adult males. Ninety six blood samples were taken from the patients attending KIRAN Hospital, The Lab., in which 41 were confirmed cases of prostate cancer and 55 individuals having unknown diseases of prostate gland (prostatitis etc). Their age and bone scan results have been recorded. IRMA estimated tumor marker PSA by using PSA kit supplied by immunotech, a Beckman coulter company. RIA technique was used to detect prostate specific antigens. Serum alkaline phosphatase was detected in Selectra automated analyzer. All tests were performed as described by the manufacturer. In case of malignancy, 53.6 cases showed the abnormal PSA level(>4 ng dL-1). While 46.34% individuals had normal PSA level (0-4 ng dL-1). There was a greater elevation in PSA level in the patients with prostate cancer as compare to bone scan and alkaline phosphatase. PSA has significant correlation with alkaline phosphatase, prostate cancer was easily diagnosed when PSA level was above 100 ng dL-1. Bone scan has the importance when PSA level is above 100 ng dL-1. Hemoglobin is greatly affected and showed less than normal values and nearly same effect was observed on lymphocytes, PSA level increases in cancer patients also in non cancerous patients.

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How to cite this article
Tanveer Khanum, Ajaz Rasool, M. Hanif, Samreen Idrees, Shahid Kamal, Aliya Hayat and Rafia Azmat, 2005. Significance of Prostate Specific Antigen for the Diagnosis and Treatment of Prostate Cancer. Pakistan Journal of Biological Sciences, 8: 1798-1801.

Keywords: Prostate cancer, PSA (Prostate Specific Antigens), alkaline phosphatase, bone scan and RIA (Radio Immunoassay

REFERENCES
  • Silverberg, E., C.C. Boring and T.S. Squires, 1990. Cancer statistics. CA. Cancer J. Clin., 40: 9-26.

  • Hsing, A.W., L. Tsao and S.S. Devesa, 2000. International trend and patterns of prostate cancer incid ence and mortality. Int. Cancer, 85: 60-65.
    PubMed    

  • Gillatt, D. and J.M. Reynard, 1995. What is normal range for prostate specific antigen use of a receiver operating charecteristic curve to evaluate a serum marker. Br. J. Urol., 75: 341-346.
    Direct Link    

  • Fried, R.M., N.S. Davis and G.H. Weiss, 1997. Prostate cancer screening and management. Med. Clin. North Am., 81: 801-801.

  • Wang, M.C., L.A. Velenzuelae and G.A. Murphy, 1979. Purification of a human serum prostate specific antigen. Invest. Urol., 17: 159-159.

  • Catalona,W.J., F.R.R. Ahmed, F.R. Ahmann, M.A. Hudson and P.T. Scardino et al., 1994. Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer. J. Urol., 151: 1283-1290.
    PubMed    

  • Wahner, H.W. and M.L. Brown, 1988. Role of Bone Scanning. In: Diagnosis and Management of Metatstatic Bone Diseases, Sim, F.H. (Eds.). Reven Press, New York, pp: 51-67

  • Bishop, M.C., J.G. Hardy, M.C.M. L. Taylor Wastie and R.J. Lemberger, 1985. Bone imaging and serum phosphatases in prostatic carcinoma. Br. J. Urol., 57: 317-324.
    PubMed    

  • Chybowski, F.M., J.J. Keller, E.J. Bergstralh and J.E. Oesterling, 1991. Predicting radionuclide bone scan findings in patients with newly diagnosed untreated prostate cancer prostate specific antigen is superior to all other clinical parameters. J. Urol., 145: 313-318.
    PubMed    

  • Balk, S.P., Y.J. Ko and G.J. Bubley, 2003. Biology of prostate-specific antigen. J. Clin. Oncol., 21: 383-391.
    Direct Link    

  • Saima, N., A. Sarah, G. Farkhanda, S.B. Nadeem and A. Waheed, 2004. Free and total prostate specific antigen in benign prostatic hyperplasia and prostate cancer. J. Coll. Physicians. Surg. Pak., 14: 69-71.

  • Oesterling, J.E., 1991. Prostate specific antigen a critical assessment of most useful tumor marker for adenocarcinoma of the prostate. J. Urol., 145: 907-923.
    PubMed    

  • Javaid, M.S., M. Tariq, I.A. Bajwa, A. Mubashir, K.A. Shamim, A. Ahmed and F. Khan, 1996. Prostate specific antigen and bone scan correlation in the staging of patients with carcinoma prostate. Ann. King Edward Med. Coll., 2: 35-37.
    Direct Link    

  • Donoghue, O., E.P.N. Constable, A.R. Sherwood, T. Stevenson and Chisholm, 1978. Bone scanning and plasma phosphates in carcinoma of prostate. Br. J. Urol., 50: 172-172.

  • Osterling, J.E., S.J. Jacobes, C.G. Chute, H.A Guess, C.J. Girmanh, L.A. Panser and M.M. Lieber, 1993. Serum prostate specific antigen in a community based population of healthy men establishment of age-specific ranges. JAMA, 270: 860-864.
    PubMed    

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