Effects of Oral Administration of Water Extract of Nigella sativa on
Serum Concentrations of Insulin and Testosterone in Alloxan-induced Diabetic
Rats
Abstract:
The present study was designed to evaluate the role of a medicinal plant for
management of diabetes instead of manufactured drugs that led to much
complication. Water extract of Nigella sativa was investigated for
hypoglycemic effect in diabetic rats in addition to some hormones related to
diabetes mellitus. The extract induced significant reduction in serum glucose
from (7.83±1.25) to (6.7±1.10), serum insulin increased from (0.55±0.08) to
(0.65±0.06) and testosterone concentration significantly increased in treated
diabetic animals (7.58±0.21) compared to diabetic animals (6.63±0.58). The
results suggest the beneficial role of N. sativa as hypoglycemic agents
and as a protective effect against pancreatic β-cells damage from alloxan induced
diabetes in rats by decreasing oxidative stress and preserving pancreatic β-cells
integrity and also suggest that the anti diabetic effect of N. sativa may
be attributed to increased glucose metabolism. This in turn produces increase
level of insulin in serum and testosterone concentration. Which might be related
with the functional activity of the reproductive glands and the correlation with
the functional state of the pancreatic β-cells.
How to cite this article
Kamal Mohmoud Saleh Mansi , 2005. Effects of Oral Administration of Water Extract of Nigella sativa on
Serum Concentrations of Insulin and Testosterone in Alloxan-induced Diabetic
Rats. Pakistan Journal of Biological Sciences, 8: 1152-1156.
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