Abstract: Nile tilapia (Oreochromis niloticus) were sampled at four locations along Lake Maryut for eleven metal residues. Data were compared to certified levels for possible metal contamination. Generally, cadmium, lead, mercury, manganese and copper were above standard levels for unpolluted waters. The kidneys in O. niloticus were the principal store organs for most of the metals tested. In an outstanding result, the muscular edible tissue in O. niloticus was the principal destination for mercury. The majority of metals investigated as cadmium, copper, lead, mercury, zinc, chromium, cobalt, manganese and nickel exceeded most known accepted levels in fish tissue. Water lead seemed to correlate better with lead in composites of whole fish than in solitary organs. Mercury in water and fish tissue (particularly, the edible portion) exceeded all credited levels for human consumption and the protection of fish and predator, thus posing an inevitable hazard to the whole ecosystem of the lake, probably for 100 years to come.