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Journal of Biological Sciences

Year: 2006 | Volume: 6 | Issue: 1 | Page No.: 160-163
DOI: 10.3923/jbs.2006.160.163
Analgesic and Anti-inflammatory Principle from Sida cordifolia Linn
Ranajit Kumar Sutradhar, AKM Matior Rahman, Mesbahuddin Ahmad, Sitesh Chandra Bachar and Achinto Saha.

Abstract: A new flavonol glycoside, 3`-(3``,7``-dimethyl- 2``,6``-octadiene)-8-C-ß-D-glucosyl-kaempferol 3-O-ß-D-glucoside[1], isolated from Sida cordifolia Linn. was investigated for analgesic and anti-inflammatory activities in animal models. In the acetic acid induced writhing model, the drug at a dose of 25 and 50 mg kg-1 body weight showed statistically significant (p<0.0001) inhibition of writhing response of 25.12 and 52.30%, respectively. The drug also produced significant increase in the tail flick latency in a dose depended manner (r = 0.92) which were also statistically significant (p<0.0001). In carrageenan induced rat paw edema the compound produced 16.15 and 28.52% inhibition of paw edema at doses of 25 and 50 mg kg-1 body weight at the 3rd h of study.

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How to cite this article
Ranajit Kumar Sutradhar, AKM Matior Rahman, Mesbahuddin Ahmad, Sitesh Chandra Bachar and Achinto Saha., 2006. Analgesic and Anti-inflammatory Principle from Sida cordifolia Linn. Journal of Biological Sciences, 6: 160-163.

Keywords: Sida cordifolia Linn, analgesic activity, anti-inflammatory activity, acetic acid induced writhing, radient heat tail flick and carrageenan induced paw edema

REFERENCES

  • Chadha, Y.R., 1989. The Wealth of India. Vol. 9, Publications and Information Directorate, CSIR, New Delhi, pp: 323-324


  • Kirtikar, K.R. and B.D. Basu, 1980. Indian Medicinal Plants. 2nd Edn., MP Singh and BP Singh, UK


  • Chopra, R.N., K.L. Handa and L.D. Kapur, 1958. Chopras Indigenous Drugs of India. 2nd Edn., Academic Publishers, India, pp: 409


  • Yusuf, M. and M. Kabir, 1999. Medicinal plants of Bangladesh. Bangladesh Council of Scientific and Industrial Research, Dhaka, Bangladesh, pp: 226


  • Asha, B. and N.R. Bannerjee, 1985. Polarographic studies on active constituents of Sida cordifolia. Curr. Sci., 54: 690-692.


  • Gunatilaka, A.A.L., S. Sotheeswaran, S. Balasubramaniam, A.I. Chandrasekara and H.T. Sriyani, 1980. Studies on medicinal plants of Sri Lanka. III. Pharmacologically important alkaloids of some sida species. Planta Med., 39: 66-72.
    PubMed    


  • Ghosh, S. and A. Dutt, 1930. Chemical examination of Sida cordifolia Linn. J. Ind. Chem. Soc., 7: 825-829.


  • Whittle, B.A., 1964. The use of changes in capillary permeability in mice to distinguish between narcotic and non narcotic analgesics. Br. J. Pharmacol. Chemother., 22: 246-253.
    Direct Link    


  • D'Amour, F.E. and D.L. Smith, 1941. A method for determining loss of pain sensation. J. Pharmacol. Exp. Ther., 72: 74-79.
    Direct Link    


  • Winter, C.A., E.A. Risley and G.W. Nuss, 1962. Carrageenin-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs. Exp. Biol. Med., 111: 544-547.
    CrossRef    PubMed    Direct Link    


  • Ribeiro, R.A., M.L. Vale, S.M. Thomazzi, A.B.P. Paschoalato, S. Poole, S.H. Ferreira and F.Q. Cunha, 2000. Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice. Eur. J. Pharmacol., 387: 111-118.
    CrossRef    PubMed    Direct Link    


  • Voilley, N., 2004. Acid-Sensing Ion Channels (ASICs): New targets for the analgesic effects of Non-Steroid Anti-Inflammatory Drugs (NSAIDs). Curr. Drug Targets Inflamm. Allergy, 3: 71-79.
    PubMed    Direct Link    


  • Vogel, H.G. and W.H. Vogel, 1997. Pharmacological Assays. Springer Verlag, Germany, pp: 368-370


  • Vinegar, R., W. Schreiber and R. Hugo, 1969. Biphasic development of carrageenin oedema in rats. J. Pharmacol. Exp. Therapeutics, 166: 96-103.
    PubMed    Direct Link    


  • Crunkhorn, P. and S.C.R. Meacock, 1971. Mediators of the inflammation induced in the rat paw by carrageenin. Br. J. Pharmacol., 42: 392-402.
    CrossRef    PubMed    Direct Link    


  • Rosa, M.D. and D.A. Willoughby, 1971. Screens for anti inflammatory drugs. J. Pharm. Pharmacol., 23: 297-298.

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