Abstract: Successive hexane, ethyl acetate and methanol extracts of Desmodium triflorum DC were subjected to evaluate analgesic and anti-inflammatory activities in animal model. In acetic acid-induced writhing test, the ethyl acetate extract at doses of 150 and 300 mg kg 1 body weight elicited 47.60 and 57.40% inhibition of writhing reflex, respectively but the methanol extract showed 51.48% inhibition at 300 mg kg 1 body weight. Significant elongation of tail flick time was evident both in ethyl acetate and methanol extracts (69.54 and 61.72% elongation, respectively) only at the higher dose. Both the hexane and methanol extracts at a dose of 300 mg kg 1 body weight showed statistically significant (p<0.01) inhibition of rat paw edema by 35.8 and 38.97%, respectively at the third hour after carrageenan injection.