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Journal of Biological Sciences

Year: 2005 | Volume: 5 | Issue: 5 | Page No.: 562-567
DOI: 10.3923/jbs.2005.562.567
Angiotensin and Arginine Vasopressin Receptor Subtypes of the Lateral Preoptic Area Effect on the Sodium Balance
Wilson Abrao Saad, Luiz Antonio de Arruda Camargo, Jose Antunes-Rodrigues, William Abrao Saad, Ismael Franscisco Motta Sigueira Guarda and Renata Saad Guarda

Abstract: It was speculated whether the influence of lateral pvasopressin (AVP) and angiotensin (ANG II). The present study investigated the effects of central administration of specific AVP and ANG II antagonists (d(CH2)5-Tyr (Me)-AVP (AAVP) and [Adamanteanacetyl1, 0-ET-D-Tyr2, Val4, Aminobutyryl6, Arg8,9]-AVP (ATAVP) antagonists of V1 and V2 receptors of AVP. Also the effects of losartan and CGP42112A (selective ligands of the AT1 and AT2 angiotensin receptors, respectively), was investigated on Na+ uptake and renal fluid and electrolyte excretion. After an acclimatization period of 7 days, the animals were maintained under tribromoethanol (200 mg kg 1 body weight, intraperitoneal) anesthesia and placed in a Kopf stereotaxic instrument. Stainless guide cannula was implanted into the LPO. AAVP and ATAVP injected into the LPO prior to AVP produced a reduction in the sodium intake responses. Both the AT1 and AT2 ligands administered into the LPO elicited a decrease in the sodium intake induced by AVP injected into the LPO, but losartan was more effective than CGP 42112A. AVP injection into LPO increased sodium renal excretion, but this was reduced by prior AAVP administration. The ATAVP produced a decreased in the natriuretic effect of AVP. The losartan injected into LPO previous to AVP decreased the sodium excretion and the CGP 421122A also decreased the natriuretic effect of AVP with a high intensity. The AVP produced an antidiuresis effect that was inhibited by prior administration into LPO of the ATAVP. The AAVP produced no change in the antidiuretic effect of AVP. These results suggest that LPO are implicated in sodium balance that is mediated by V1, V2, AT1 and AT2 receptors.

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Wilson Abrao Saad, Luiz Antonio de Arruda Camargo, Jose Antunes-Rodrigues, William Abrao Saad, Ismael Franscisco Motta Sigueira Guarda and Renata Saad Guarda, 2005. Angiotensin and Arginine Vasopressin Receptor Subtypes of the Lateral Preoptic Area Effect on the Sodium Balance. Journal of Biological Sciences, 5: 562-567.

Keywords: Vasopressin, angiotensin receptor subtypes, lateral preoptic area and sodium balance

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