Abstract: The research work was carried out to investigate the effects of oral administration of glucocorticoids (dexamethasone and prednisolone), NSAIDs (aspirin and paracetamol) and sulfonylureas (gliclazide and glibenclamide) on body weight and blood glucose in mice. Out of seven groups of mice (each containing 5 mice), one group was kept as control without giving any drug. Another six groups of mice received separately dexamethasone (Oradexon®, 3.5 mg kg-1 b.wt.) prednisolone (Deltasone®, 8 mg kg-1 b.wt.), aspirin (Ecospirin®, 620 mg kg-1 b.wt.), paracetamol (Napa®, 333 mg kg-1 b.wt.), gliclazide (Comprid®, 64 mg kg-1 b.wt.) and glibenclamide (Glucotab®, 16 mg kg-1 b.wt) orally along with normal feed. A significant (p<0.05) reduction of body weight was recorded on 7th day following administration of dexamethasone, gliclazide and glibenclamide in mice. This reduction was highly significant (p<0.01) on 21st, 42nd and 70th day following dexamethasone, gliclazide and glibenclamide treated groups. Similarly prednisolone significantly (p<0.01) reduced body weight of mice in whole experimental period. A significant (p<0.01) increase of the blood glucose level was found due to dexamethasone, prednisolone, aspirin and paracetamol administration on 7th , 21st, 42nd and 70th day. On the other hand, a significant (p<0.01) decrease of blood glucose level was found in mice treated with gliclazide and glibenclamide in whole experimental period. It may be concluded that oral administration of glucocorticoids, NSAIDs and sulfonylureas have variable effects on blood glucose level in mice.