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Journal of Biological Sciences

Year: 2003 | Volume: 3 | Issue: 12 | Page No.: 1188-1202
DOI: 10.3923/jbs.2003.1188.1202
The Inhibition of Prostaglandin Biosynthesis by Human Plasma and its Relationship to Albumin and Haptoglobin
Sheikh Arshad Saeed, Sarah Khalid Khan , Saira Abdul Aziz Samani , Kashfa Farhat , Natasha Imtiaz Hansraj , Asthma Mushir Ahmad Khan , Ameer Zaigham Rasheed , Abdul Mueed Zafar , Muhammad Ameen Rauf and Sagheer Ahmad

Abstract: Blood plasma was found to contain endogenous inhibitor of prostaglandin (PG) synthase (EIPS) and this activity was associated with at least two plasma components, albumin and haptoglobin. Hemoglobin, a stimulant of PG biosynthesis which is bound by haptoglobin, reversed the inhibitory effect of haptoglobin and reduced the inhibition by albumin, acetylsalicylate or indomethacin. It is proposed that in physiological situations the albumin-associated EIPS mainly helps to prevent excessive PG production, whereas in tissue injury the acute phase protein haptoglobin plays a more important role. Possible clinical applications of EIPS are discussed.

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How to cite this article
Sheikh Arshad Saeed, Sarah Khalid Khan , Saira Abdul Aziz Samani , Kashfa Farhat , Natasha Imtiaz Hansraj , Asthma Mushir Ahmad Khan , Ameer Zaigham Rasheed , Abdul Mueed Zafar , Muhammad Ameen Rauf and Sagheer Ahmad , 2003. The Inhibition of Prostaglandin Biosynthesis by Human Plasma and its Relationship to Albumin and Haptoglobin. Journal of Biological Sciences, 3: 1188-1202.

Keywords: laptoglobin, albumin, eips, blood plasma and hemoglobin

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