Abstract: Leaf spot disease incidence caused by Cercospora moricola Cooke was studied on five high yielding and a local variety of mulberry during the months of May to September in 2000, 2001 and 2002. Leaf infection was observed in those years. Percentage of disease incidence was calculated against Cercospora leaf spot disease in five high yielding and one local varieties. Among the six varieties the local one was found to be highly susceptible to Cercospora where the highest disease incidence (55.60%) around three years was recorded. BM-4 (16.97%) and BM-5 (18.46%) were found to be moderately resistant. On the other hand BM-1 (27.83%), BM-2 (29.82%) and BM-3 (36.99%) were identified as moderately susceptible to leaf spot disease.