Abstract: The 80% methanolic extract of Myricaria elegans Royle was investigated for in vitro acetylcholinesterase (ACHE), butyrylcholinesterase (BCHE) and lipoxygenase enzyme inhibition activities. The crude extract was found to have significant acetylcholinesterase inhibitory activity (74.8%) and remarkable butryrylcholinesterase inhibitory activity (96.0%). However, no activity was observed against the enzyme lipoxygenase (0.0%).